Korea institute of Health & Environment, 87, Seongsui-ro, Seongdong-gu, Seoul.
Department of Surgery, Inje University Ilsan Paik Hospital, 170 Juhwa-ro, IlsanSeo-gu, Goyang-si, Gyeonggi-do, Republic of Korea.
Medicine (Baltimore). 2021 Jan 8;100(1):e23994. doi: 10.1097/MD.0000000000023994.
To date research investigating the associations between handgrip strength and multimorbidity when stratifying by age and sex is limited. Furthermore, this is the first study in a Korean population, and the first to include adults ≥ 19 years of age. Here we investigated the associations between handgrip strength and multimorbidity in Korean adults aged ≥ 19 years.In this cross-sectional study data from the Korean National Health and Nutrition Examination Survey were used. Multimorbidity was defined as having 2 or more chronic diseases. A total of 19,779 participants were eligible for the study (8730 male and 11,049 female). We grouped and analysed participants based on age and sex (men and women aged 19-49 years, men and women aged 50-80 years) and examined the associations between handgrip strength and multimorbidity using multivariate logistic regressions using stratification by age, sex and body mass index (BMI).Multivariate logistic regressions revealed a significant inverse association irrespective of sex, between relative handgrip strength and multimorbidity. Participants with the lowest handgrip strength had a significantly higher odds ratio (OR) of multimorbidity (men aged 19-49 years: 3.76 and aged 50 years to 80 years: 2.11; women aged 19 years to 49 years: 1.52 and aged 50-80 years: 2.15) when compared to those with highest handgrip strength after adjusting for confounding variables. The highest OR was observed in men aged 19 years to 49 years with a BMI ≥ 25 kg/m2.In the current study we observed a significant inverse relationship between handgrip strength and multimorbidity in males and females with 2 or more chronic diseases. Male participants with a low handgrip strength aged between 19 years to 49 years with a BMI ≥25 kg/m2 may be at greater risk of multimorbidity. This study highlights the need for further longitudinal studies to investigate the effects of increasing handgrip strength combined with weight loss, as an effective strategy to reduce the incidence of multimorbidity.
目前，当按年龄和性别分层研究握力与多种疾病之间的关联时，研究有限。此外，这是在韩国人群中进行的第一项研究，也是第一项纳入≥19 岁成年人的研究。在这里，我们研究了≥19 岁韩国成年人中握力与多种疾病之间的关联。
在这项横断面研究中，使用了韩国国家健康和营养检查调查的数据。多种疾病定义为患有两种或两种以上慢性疾病。共有 19779 名参与者符合研究条件（男性 8730 名，女性 11049 名）。我们根据年龄和性别（年龄在 19-49 岁的男性和女性，年龄在 50-80 岁的男性和女性）对参与者进行分组和分析，并使用按年龄、性别和体重指数（BMI）分层的多变量逻辑回归检查握力与多种疾病之间的关联。
多变量逻辑回归显示，无论性别如何，相对握力与多种疾病之间存在显著的负相关关系。与握力最强的参与者相比，握力最弱的参与者患多种疾病的优势比（OR）显著更高（年龄在 19-49 岁的男性：3.76；年龄在 50-80 岁的男性：2.11；年龄在 19-49 岁的女性：1.52；年龄在 50-80 岁的女性：2.15），调整混杂变量后。在 BMI≥25kg/m2的情况下，19-49 岁的男性观察到的最高 OR。
在当前的研究中，我们观察到患有两种或两种以上慢性疾病的男性和女性中，握力与多种疾病之间存在显著的负相关关系。19-49 岁 BMI≥25kg/m2的低握力男性参与者可能面临更高的多种疾病风险。本研究强调需要进一步进行纵向研究，以调查增加握力和减肥相结合作为降低多种疾病发病率的有效策略的效果。
