低握力与成年人贫血密切相关：一项使用韩国国家健康和营养检查调查（KNHANES）的横断面研究。
Low handgrip strength is closely associated with anemia among adults: A cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES).
机构信息
Jaseng Hospital of Korean Medicine, Gangnam-gu, Seoul, Republic of Korea.
Department of Health Administration, Hanyang Women's University, Seongdong-gu, Seoul, South Korea.
出版信息
PLoS One. 2020 Mar 20;15(3):e0218058. doi: 10.1371/journal.pone.0218058. eCollection 2020.
BACKGROUND
Anemia, which is a major public health problem worldwide, represents a decline in the oxygenation function, and can therefore be related to low strength. However, hemoglobin cannot repair muscles directly, but is beneficial only in a supportive role. Previous studies on the relationship between handgrip strength and anemia have been controversial. Thus, we aimed to analyze the association between handgrip strength and anemia in Korean adults.
METHODS
This cross-sectional study used the 2013-2017 data from the 6th and 7th Korean National Health and Nutrition Examination Survey (KNHANES) that included 16,638 Korean adults, aged ≥19 years, who met the inclusion or exclusion criteria. Differences in sociodemographic factors (sex, age, education, income, and employment), lifestyle factors (alcohol consumption, smoking, and physical activity), and illness and health factors [body mass index (BMI), vitamin intake, iron intake, comorbid illnesses, and handgrip strength] by existence of anemia, were analyzed using the Chi square test. Binary logistic regression analysis was used to measure the association between handgrip strength and anemia, while adjusting for other possible confounders. Subgroup analysis, stratified by sex and age, was performed.
RESULTS
Among Korean adults aged ≥19 years, 745,296 (7.7%) had anemia. A higher odds ratio, adjusted for other covariates/factors (OR) of anemia occurred in the weak handgrip strength group than in the strong handgrip strength group (OR = 1.92, 95% CI: 1.58-2.33). The subgroup analysis showed a higher OR adjusted for other covariates/factors of anemia in the weak handgrip strength group than in the strong handgrip strength group, regardless of sex or age. However, the association was greater for males (OR = 2.13, 95% CI: 1.35-3.34) and for those aged ≥65 years (OR = 1.92, 95% CI: 1.42-2.58).
CONCLUSION
This study showed a strong association between handgrip strength and anemia that was particularly strong for males and those aged ≥65 years.
背景
贫血是全球范围内的一个主要公共卫生问题，代表着氧合功能的下降，因此可能与低强度有关。然而，血红蛋白不能直接修复肌肉，而只是在支持作用方面有益。之前关于握力与贫血之间关系的研究一直存在争议。因此，我们旨在分析韩国成年人中握力与贫血之间的关系。
方法
本横断面研究使用了 2013-2017 年韩国第六次和第七次全国健康和营养调查（KNHANES）的数据，该数据包括符合纳入或排除标准的 16638 名韩国成年人，年龄≥19 岁。通过贫血的存在，分析社会人口因素（性别、年龄、教育、收入和就业）、生活方式因素（饮酒、吸烟和体力活动）和疾病与健康因素（体重指数[BMI]、维生素摄入、铁摄入、合并疾病和握力）的差异。使用卡方检验分析。使用二元逻辑回归分析测量握力与贫血之间的关联，同时调整其他可能的混杂因素。按性别和年龄进行亚组分析。
结果
在年龄≥19 岁的韩国成年人中，有 745296 人（7.7%）患有贫血。与握力较强的组相比，握力较弱的组贫血的优势比（OR）更高，调整其他协变量/因素后（OR=1.92，95%CI：1.58-2.33）。亚组分析显示，调整其他协变量/因素后，握力较弱的组贫血的 OR 高于握力较强的组，无论性别或年龄如何。然而，这种关联在男性（OR=2.13，95%CI：1.35-3.34）和≥65 岁的人群中更大（OR=1.92，95%CI：1.42-2.58）。
结论
本研究表明握力与贫血之间存在很强的关联，对于男性和≥65 岁的人群尤其强烈。
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