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中国大陆地区口服用普萘洛尔和阿替洛尔治疗婴幼儿血管瘤的应用调查:普萘洛尔阿替洛尔血管瘤调查。

A survey on the application of oral propranolol and atenolol for the management of infantile hemangiomas in mainland China: Survey on propranolol atenolol hemangiomas.

机构信息

Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai.

Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

出版信息

Medicine (Baltimore). 2021 Jan 8;100(1):e24146. doi: 10.1097/MD.0000000000024146.

Abstract

Since 2008, oral propranolol has evolved as the first-line therapy for infantile hemangiomas (IHs). Meanwhile, oral atenolol gradually shows comparative effectiveness versus oral propranolol with few side effects. Here, we conducted a mobile internal survey among a group of Chinese clinicians about how they choose the dosage, dose regimen, and dose escalation methods of propranolol and atenolol for the treatment of IH.A mobile-ready internal survey on the application of oral propranolol and oral atenolol for IH in mainland China was performed and distributed to 333 potential clinicians from different levels of healthcare institutions in mainland China. Eighty-one doctors responded to the survey. All the respondents had the experience of treating IH with oral propranolol and 32 had the experience with oral atenolol.Most of the doctors from tertiary hospitals chose 2 mg/kg/d twice daily, while most of those with the experience of propranolol from private hospitals chose 1 mg/kg/d once daily. More doctors from tertiary hospitals had the experience of atenolol than those from private hospitals.Oral atenolol has become another medication intervention option for IH in mainland China. This survey is helpful to standardize and develop a guideline of oral atenolol therapy for IH.

摘要

自 2008 年以来,普萘洛尔口服制剂已成为婴幼儿血管瘤(IH)的一线治疗药物。同时,口服阿替洛尔在不良反应较少的情况下,逐渐显示出与普萘洛尔相当的疗效。在这里,我们对一组中国临床医生进行了一项移动内部调查,了解他们如何选择普萘洛尔和阿替洛尔治疗 IH 的剂量、剂量方案和剂量递增方法。

在中国内地,我们对普萘洛尔和阿替洛尔治疗 IH 的应用进行了一项可移动的内部调查,并分发给来自中国内地不同医疗机构级别的 333 名潜在临床医生。81 名医生对该调查做出了回应。所有的受访者都有使用普萘洛尔治疗 IH 的经验,32 名受访者有使用阿替洛尔的经验。

大多数来自三甲医院的医生选择 2mg/kg/d,每日两次,而大多数来自私立医院有普萘洛尔治疗经验的医生选择 1mg/kg/d,每日一次。来自三甲医院的医生比来自私立医院的医生有更多的阿替洛尔治疗经验。

口服阿替洛尔已成为中国内地治疗 IH 的另一种药物干预选择。该调查有助于规范和制定 IH 口服阿替洛尔治疗指南。

相似文献

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Propranolol therapy for infantile hemangioma: our experience.普萘洛尔治疗婴儿血管瘤:我们的经验。
Drug Des Devel Ther. 2017 May 8;11:1401-1408. doi: 10.2147/DDDT.S134808. eCollection 2017.

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