Chen Yung-Lung, Chuang Jiin-Haur, Wang Hui-Ting, Chen Huang-Chung, Liu Wen-Hao, Yang Ming-Yu
Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Diagnostics (Basel). 2021 Jan 7;11(1):90. doi: 10.3390/diagnostics11010090.
A prominent circadian variation is present in atrial fibrillation (AF) attacks that may be related to the expression of circadian clock genes. Little is known about the expression of circadian clock genes in AF. We prospectively enrolled 73 patients who had received pacemaker implantation, in order to define the burden of atrial high-rate episodes (AHREs) accurately. AF was diagnosed clinically in 43 (59%) patients (15 with persistent AF and 28 with paroxysmal AF). The expression levels of circadian clock genes of peripheral blood leukocytes were checked. There were more males and patients with a larger left atrial (LA) size and lower expression levels of , , , , , , , and genes in persistent AF group than in other groups. There was a significant correlation between higher AHRE burden and larger LA size and between higher AHRE burden and decreased expression of circadian clock genes in patients with AF. LA volume and the expression of , , and are significantly associated with AHRE burden. However, the underlying mechanism needs to be elucidated in further studies.
心房颤动（AF）发作存在显著的昼夜节律变化，这可能与昼夜节律钟基因的表达有关。关于AF中昼夜节律钟基因的表达知之甚少。我们前瞻性地纳入了73例接受起搏器植入的患者，以便准确界定心房高频率发作（AHREs）的负荷。43例（59%）患者临床诊断为AF（15例持续性AF和28例阵发性AF）。检测外周血白细胞中昼夜节律钟基因的表达水平。与其他组相比，持续性AF组男性更多，左心房（LA）更大，且、、、、、、、和基因的表达水平更低。AF患者中，较高的AHRE负荷与较大的LA大小以及较高的AHRE负荷与昼夜节律钟基因表达降低之间存在显著相关性。LA容积以及、和的表达与AHRE负荷显著相关。然而，其潜在机制需要在进一步研究中阐明。
