Yang Jingyi, Zhao Junxin, Chen Zhuoyang, Duan Lincheng, Yang Hong, Cai Dingjun
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Key Laboratory of Acupuncture for Senile Disease (Chengdu University of TCM), Ministry of Education/Acupuncture and Chronobiology Key Laboratory of Sichuan Province, Chengdu 611137, China.
Int J Mol Sci. 2025 May 12;26(10):4626. doi: 10.3390/ijms26104626.
The biological clock is crucial for controlling the circadian rhythm of the human body and maintaining the stable cyclic changes of various human life activities. Cardiovascular disease has become one of the primary problems affecting human life and health in today's society. Cardiovascular disease exhibits distinct circadian rhythms, with the core clock gene protein Brain and muscle ARNT-like protein 1 (BMAL1) playing critical roles in both physiological cardiac function and pathological processes. BMAL1 regulates myocardial gene expression, maintains normal structures, and stabilizes circadian rhythms to preserve cardiac homeostasis. In the pathological state of myocardial ischemia, BMAL1 ameliorates myocardial ischemic injury by regulating intrinsic mechanisms such as oxidative stress response, energy metabolism, immune-inflammatory response, and apoptosis and autophagy in cardiomyocytes. This review systematically examines BMAL1's involvement in myocardial ischemic injury through the circadian regulation of cardiac function. We analyze its multidimensional impacts on oxidative stress, energy metabolism, immune-inflammatory responses, apoptosis, and autophagy, highlighting the biological significance of this clock gene in ischemic pathophysiology.
生物钟对于控制人体的昼夜节律以及维持人类各种生命活动的稳定周期性变化至关重要。心血管疾病已成为当今社会影响人类生活和健康的主要问题之一。心血管疾病呈现出明显的昼夜节律，核心时钟基因蛋白脑和肌肉芳香烃受体核转运蛋白样蛋白1（BMAL1）在心脏生理功能和病理过程中均发挥着关键作用。BMAL1调节心肌基因表达，维持正常结构，并稳定昼夜节律以维持心脏内环境稳态。在心肌缺血的病理状态下，BMAL1通过调节氧化应激反应、能量代谢、免疫炎症反应以及心肌细胞中的凋亡和自噬等内在机制来减轻心肌缺血损伤。本综述通过对心脏功能的昼夜调节系统地研究了BMAL1在心肌缺血损伤中的作用。我们分析了其对氧化应激、能量代谢、免疫炎症反应、凋亡和自噬的多维度影响，突出了这个时钟基因在缺血病理生理学中的生物学意义。
