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小肠因子在体外促进蓝氏贾第鞭毛虫的包囊形成。

Small-intestinal factors promote encystation of Giardia lamblia in vitro.

作者信息

Gillin F D, Reiner D S, Boucher S E

机构信息

Department of Pathology, University of California San Diego 92103.

出版信息

Infect Immun. 1988 Mar;56(3):705-7. doi: 10.1128/iai.56.3.705-707.1988.

DOI:10.1128/iai.56.3.705-707.1988
PMID:3343054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC259350/
Abstract

Bile salts and fatty acids stimulated differentiation of cultured Giardia lamblia trophozoites into water-resistant cysts at the slightly alkaline pH of the small intestinal lumen. Maximum encystation occurred at pH 7.8. Thus, specific small-intestinal factors may influence encystation in vivo as well as in vitro.

摘要

胆汁盐和脂肪酸在小肠肠腔略呈碱性的pH值条件下，刺激培养的蓝氏贾第鞭毛虫滋养体分化为耐水包囊。最大包囊化发生在pH 7.8时。因此，特定的小肠因子可能在体内和体外都影响包囊化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e86/259350/89a26dd08f87/iai00075-0177-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e86/259350/89a26dd08f87/iai00075-0177-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e86/259350/89a26dd08f87/iai00075-0177-a.jpg

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引用本文的文献

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Recent advances in functional research in Giardia intestinalis.肠道贾第虫功能研究的最新进展。
Adv Parasitol. 2020;107:97-137. doi: 10.1016/bs.apar.2019.12.002. Epub 2020 Feb 5.
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Lactoferrin and lactoferricin endocytosis halt Giardia cell growth and prevent infective cyst production.乳铁蛋白和乳铁蛋白肽的内吞作用会阻止贾第虫细胞生长并防止感染性囊形成。

本文引用的文献

1
On the concentration of bile acids in the human intestine during absorption. Bile acids and sterioids 74.关于人体肠道吸收过程中胆汁酸的浓度。胆汁酸与类固醇74。
Acta Physiol Scand. 1959 Aug 31;46:339-45. doi: 10.1111/j.1748-1716.1959.tb01763.x.
2
The influence of bile salt structure on self-association in aqueous solutions.胆汁盐结构对其在水溶液中自缔合的影响。
J Biol Chem. 1983 May 25;258(10):6362-70.
3
Giardia lamblia infection of suckling mice.乳鼠的贾第虫感染。
Sci Rep. 2018 Dec 21;8(1):18020. doi: 10.1038/s41598-018-36563-1.
4
Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells.贾第虫与人类肠道上皮细胞相互作用期间的分泌蛋白组特征：对宿主细胞的影响
PLoS Negl Trop Dis. 2017 Dec 11;11(12):e0006120. doi: 10.1371/journal.pntd.0006120. eCollection 2017 Dec.
5
Colonizes and Encysts in High-Density Foci in the Murine Small Intestine.在小鼠小肠的高密度病灶中定殖并形成包囊。
mSphere. 2017 Jun 21;2(3). doi: 10.1128/mSphere.00343-16. eCollection 2017 May-Jun.
6
Transcriptomic Profiling of High-Density Foci Encysting in the Murine Proximal Intestine.小鼠近端肠道中形成包囊的高密度病灶的转录组分析
Front Cell Infect Microbiol. 2017 May 31;7:227. doi: 10.3389/fcimb.2017.00227. eCollection 2017.
7
Giardia Alters Commensal Microbial Diversity throughout the Murine Gut.贾第虫改变小鼠整个肠道内共生微生物的多样性。
Infect Immun. 2017 May 23;85(6). doi: 10.1128/IAI.00948-16. Print 2017 Jun.
8
Rac Regulates Giardia lamblia Encystation by Coordinating Cyst Wall Protein Trafficking and Secretion.Rac通过协调囊壁蛋白的运输和分泌来调节蓝氏贾第鞭毛虫的包囊化过程。
mBio. 2016 Aug 23;7(4):e01003-16. doi: 10.1128/mBio.01003-16.
9
Infection Strategies of Intestinal Parasite Pathogens and Host Cell Responses.肠道寄生虫病原体的感染策略与宿主细胞反应
Front Microbiol. 2016 Mar 3;7:256. doi: 10.3389/fmicb.2016.00256. eCollection 2016.
10
A systematic review and meta-analysis of the association between Giardia lamblia and endemic pediatric diarrhea in developing countries.发展中国家蓝氏贾第鞭毛虫与地方性小儿腹泻的关联：系统评价和荟萃分析。
Clin Infect Dis. 2012 Dec;55 Suppl 4(Suppl 4):S271-93. doi: 10.1093/cid/cis762.
J Infect Dis. 1983 Feb;147(2):217-21. doi: 10.1093/infdis/147.2.217.
4
Axenic culture of Giardia lamblia in TYI-S-33 medium supplemented with bile.在添加胆汁的TYI-S-33培养基中对蓝氏贾第鞭毛虫进行无病原体培养。
Trans R Soc Trop Med Hyg. 1983;77(4):487-8. doi: 10.1016/0035-9203(83)90120-7.
5
Mammalian bile promotes growth of Giardia lamblia in axenic culture.哺乳动物胆汁可促进贾第虫在无菌培养中的生长。
Trans R Soc Trop Med Hyg. 1983;77(4):467-9. doi: 10.1016/0035-9203(83)90115-3.
6
Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem.
J Lipid Res. 1984 Dec 15;25(13):1477-89.
7
Chemistry and enterohepatic circulation of bile acids.胆汁酸的化学性质与肠肝循环
Hepatology. 1984 Sep-Oct;4(5 Suppl):4S-14S. doi: 10.1002/hep.1840040803.
8
Ionic constituents and osmolality of gastric and small-intestinal fluids after eating.进食后胃和小肠液的离子成分及渗透压
Am J Dig Dis. 1966 Jul;11(7):503-21. doi: 10.1007/BF02233563.
9
Killing of Giardia lamblia by human milk lipases: an effect mediated by lipolysis of milk lipids.
J Infect Dis. 1986 Apr;153(4):715-20. doi: 10.1093/infdis/153.4.715.
10
Human milk kills Giardia lamblia by generating toxic lipolytic products.人乳通过产生有毒的脂解产物杀死贾第鞭毛虫。
J Infect Dis. 1986 Nov;154(5):825-32. doi: 10.1093/infdis/154.5.825.