静脉注射前列腺素E和内毒素对雏鸡的一些影响。
Some effects of intravenous prostaglandin E, and endotoxin in young chickens.
作者信息
Artunkal A A, Marley E, Stephenson J D
出版信息
Br J Pharmacol. 1977 Sep;61(1):29-37. doi: 10.1111/j.1476-5381.1977.tb09736.x.
Abstract
1 The effects of intravenous prostaglandin E1 and endotoxin were studied in young chickens (11-17 days old). 2 At a thermoneutral ambient temperature (31 degrees C), intravenous prostaglandin E1, produced behavioural and electrocortical sleep, increased oxygen consumption and, after an initial fall, elevated body temperature. Below thermoneutrality (16 degrees C), the initial hypothermic effect was more marked and oxygen consumption was lowered. 3 The soporific actions of prostaglandin E1 were sufficient to counteract dexamphetamine-induced behavioural and electrocortical arousal and vocalization. 4 Intravenous injection of the O-somatic antigen of Shigella dysenteriae evoked, after a latent period, long lasting hyperthermia. This indicates that in young chicks the blood brain barrier is probably permeable to endotoxins.
摘要
- 研究了静脉注射前列腺素E1和内毒素对幼鸡（11 - 17日龄）的影响。2. 在热中性环境温度（31摄氏度）下，静脉注射前列腺素E1会产生行为性和皮层脑电图睡眠，增加耗氧量，并在最初下降后使体温升高。在低于热中性温度（16摄氏度）时，最初的低温效应更明显，耗氧量降低。3. 前列腺素E1的催眠作用足以抵消右旋苯丙胺引起的行为性和皮层脑电图觉醒及发声。4. 静脉注射痢疾志贺氏菌的O-菌体抗原，经过一段潜伏期后，会引起持久的体温过高。这表明在幼鸡中，血脑屏障可能对内毒素具有通透性。
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J Neurochem. 1957;1(3):216-27. doi: 10.1111/j.1471-4159.1957.tb12075.x.
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Br J Pharmacol Chemother. 1965 Dec;25(3):671-81. doi: 10.1111/j.1476-5381.1965.tb01792.x.
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6
7
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