Department of Pharmaceutical Science and Research, School of Pharmacy, Marshall University, Huntington, WV, United States.
Curr Drug Deliv. 2021;18(8):1064-1084. doi: 10.2174/1567201818666210111101257.
Chronic wounds remain a significant public problem and the development of wound treatments has been a research focus for the past few decades. Despite advances in the products derived from endogenous substances involved in a wound healing process (e.g., growth factors, stem cells, and extracellular matrix), effective and safe wound therapeutics are still limited. There is an unmet need to develop new therapeutics. Various new pathways and targets have been identified and could become a molecular target in designing novel wound agents. Importantly, many existing drugs that target these newly identified pathways could be repositioned for wound therapy, which will facilitate fast translation of research findings to clinical applications. This review discusses the newly identified pathways/targets and their potential uses in the development of wound therapeutics. Some herbs and amphibian skins have been traditionally used for wound repairs and their active ingredients have been found to act in these new pathways. Hence, screening these natural products for novel wound therapeutics remains a viable approach. The outcomes of wound care using natural wound therapeutics could be improved if we can better understand their cellular and molecular mechanisms and fabricate them in appropriate formulations, such as using novel wound dressings and nano-engineered materials. Therefore, we also provide an update on the advances in wound therapeutics from natural sources. Overall, this review offers new insights into novel wound therapeutics.
慢性伤口仍然是一个重大的公共问题，过去几十年来，伤口治疗的发展一直是研究的重点。尽管在参与伤口愈合过程的内源性物质（例如生长因子、干细胞和细胞外基质）衍生产品方面取得了进展，但有效的和安全的伤口治疗仍然有限。因此，仍然需要开发新的治疗方法。已经确定了各种新的途径和靶点，它们可能成为设计新型伤口制剂的分子靶标。重要的是，许多针对这些新鉴定的途径的现有药物可以重新定位用于伤口治疗，这将促进研究发现快速转化为临床应用。本文综述了新发现的途径/靶点及其在伤口治疗开发中的潜在用途。一些草药和两栖动物皮肤传统上用于伤口修复，其活性成分被发现作用于这些新途径。因此，筛选这些天然产物以开发新型伤口治疗方法仍然是一种可行的方法。如果我们能够更好地了解它们的细胞和分子机制，并将其制成合适的制剂，例如使用新型伤口敷料和纳米工程材料，那么使用天然伤口治疗方法进行伤口护理的结果可能会得到改善。因此，我们还提供了天然来源的伤口治疗进展的最新信息。总的来说，本文为新型伤口治疗方法提供了新的见解。
