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电纺草药纳米纤维的最新进展。

Recent Progress of Electrospun Herbal Medicine Nanofibers.

机构信息

School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.

School of Health Sciences, Caritas Institute of Higher Education, Hong Kong 999077, China.

出版信息

Biomolecules. 2023 Jan 16;13(1):184. doi: 10.3390/biom13010184.

DOI:10.3390/biom13010184
PMID:36671570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9855805/
Abstract

Herbal medicine has a long history of medical efficacy with low toxicity, side effects and good biocompatibility. However, the bioavailability of the extract of raw herbs and bioactive compounds is poor because of their low water solubility. In order to overcome the solubility issues, electrospinning technology can offer a delivery alternative to resolve them. The electrospun fibers have the advantages of high specific surface area, high porosity, excellent mechanical strength and flexible structures. At the same time, various natural and synthetic polymer-bound fibers can mimic extracellular matrix applications in different medical fields. In this paper, the development of electrospinning technology and polymers used for incorporating herbal medicine into electrospun nanofibers are reviewed. Finally, the recent progress of the applications of these herbal medicine nanofibers in biomedical (drug delivery, wound dressing, tissue engineering) and food fields along with their future prospects is discussed.

摘要

草药具有悠久的医疗功效历史，毒性低、副作用小、生物相容性好。然而，由于其水溶性低，草药提取物和生物活性化合物的生物利用度较差。为了克服溶解度问题，静电纺丝技术可以提供一种替代的传递方式来解决这些问题。静电纺丝纤维具有比表面积大、孔隙率高、机械强度好、结构灵活等优点。同时，各种天然和合成聚合物结合的纤维可以模拟细胞外基质在不同医学领域的应用。本文综述了静电纺丝技术的发展以及用于将草药掺入静电纺丝纳米纤维中的聚合物。最后，讨论了这些草药纳米纤维在生物医学（药物输送、伤口敷料、组织工程）和食品领域的应用的最新进展及其未来前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/805fca640b50/biomolecules-13-00184-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/3e483f134e56/biomolecules-13-00184-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/ae7aba9a7aa5/biomolecules-13-00184-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/37108b482b34/biomolecules-13-00184-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/8f8caa85059d/biomolecules-13-00184-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/49fcf0537ef9/biomolecules-13-00184-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/26612e46025a/biomolecules-13-00184-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/e4392ee92378/biomolecules-13-00184-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/7541633e06cf/biomolecules-13-00184-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/533e2d00f490/biomolecules-13-00184-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/2ff8b8395bd1/biomolecules-13-00184-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/cdc5991661b7/biomolecules-13-00184-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/d2e61054b18c/biomolecules-13-00184-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/d0786e4f000c/biomolecules-13-00184-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/805fca640b50/biomolecules-13-00184-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/3e483f134e56/biomolecules-13-00184-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/ae7aba9a7aa5/biomolecules-13-00184-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/37108b482b34/biomolecules-13-00184-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/8f8caa85059d/biomolecules-13-00184-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/49fcf0537ef9/biomolecules-13-00184-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/26612e46025a/biomolecules-13-00184-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/e4392ee92378/biomolecules-13-00184-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/7541633e06cf/biomolecules-13-00184-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/533e2d00f490/biomolecules-13-00184-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/2ff8b8395bd1/biomolecules-13-00184-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/cdc5991661b7/biomolecules-13-00184-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/d2e61054b18c/biomolecules-13-00184-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/d0786e4f000c/biomolecules-13-00184-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f2/9855805/805fca640b50/biomolecules-13-00184-g014.jpg

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