Mesbahzadeh Behzad, Salarjavan Hossein, Samarghandian Saeed, Farkhondeh Tahereh
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Curr Mol Pharmacol. 2021;14(5):894-899. doi: 10.2174/1874467214666210111105321.
Age-dependent toxic effects of organophosphorus pesticides (OPs) have not been fully understood. The current study aimed to investigate the cardiotoxic damage of chlorpyrifos (CPF) by evaluating oxidative modifications in young (2-month old), middle-aged (10- month old), and aged (20-month old) rats.
Five mg/kg of CPF was administered orally for 45 days to young, middle-aged, and aged male Wistar rats. In the end, animals were anesthetized and the heart of each rat was dissected for biochemical assay.
Malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), total antioxidant capacity (TAC), and superoxide dismutase (SOD) were assessed in the cardiac tissue of rats.
The results indicated an increase in the levels of MDA and NO, and also a decline in the levels of GSH and TAC as well as a decrease in the SOD activity in the heart of aged rats compared with young rats. CPF administration deteriorated these changes in the heart of exposed rats compared with the age-matched controls. Additionally, these oxidative modifications were more severe in aged rats versus other age.
In conclusion, advancing age may increase oxidative changes in the heart of animals exposed to CPF. It is suggested that aging can affect cardiac toxicity induced by OPs.
有机磷农药（OPs）的年龄依赖性毒性作用尚未完全明确。本研究旨在通过评估年轻（2个月大）、中年（10个月大）和老年（20个月大）大鼠的氧化修饰情况，来探究毒死蜱（CPF）对心脏的毒性损害。
对年轻、中年和老年雄性Wistar大鼠口服给予5mg/kg的CPF，持续45天。最后，将动物麻醉，解剖每只大鼠的心脏进行生化检测。
对大鼠心脏组织中的丙二醛（MDA）、一氧化氮（NO）、谷胱甘肽（GSH）、总抗氧化能力（TAC）和超氧化物歧化酶（SOD）进行评估。
结果表明，与年轻大鼠相比，老年大鼠心脏中MDA和NO水平升高，GSH和TAC水平下降以及SOD活性降低。与年龄匹配的对照组相比，给予CPF使暴露大鼠心脏中的这些变化恶化。此外，与其他年龄段相比，这些氧化修饰在老年大鼠中更为严重。
总之，年龄增长可能会增加暴露于CPF的动物心脏中的氧化变化。提示衰老会影响OPs诱导的心脏毒性。
