Institute of Quantum Beam Science, Ibaraki University, 2-1-1, Bunkyo, Mito, Ibaraki, 310-8512, Japan.
New Industry Creation Hatchery Center, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, 980-8577, Japan.
Anal Sci. 2021;37(1):49-59. doi: 10.2116/analsci.20SAR05.
A nanoporous material has been applied for the development of functional nanobiomaterials by utilizing its uniform pore structure and large adsorption capacity. The structure and stability of biomacromolecules, such as peptide, oligonucleotide, and protein, are primary factors to govern the performance of nanobiomaterials, so that their direct characterization methodologies are in progress. In this review, we focus on recent topics in the structural characterization of protein molecules adsorbed at a nanoporous material with uniform meso-sized pores. The thermal stabilities of the adsorbed proteins are also summarized to discuss whether the structure of the adsorbed protein molecules can be stabilized or not.
一种纳米多孔材料因其均匀的孔结构和较大的吸附能力，被应用于功能性纳米生物材料的开发。生物大分子（如肽、寡核苷酸和蛋白质）的结构和稳定性是决定纳米生物材料性能的主要因素，因此，它们的直接表征方法正在不断发展。在这篇综述中，我们主要关注在具有均匀中孔的纳米多孔材料上吸附的蛋白质分子的结构表征的最新研究进展。同时，我们还总结了吸附蛋白质的热稳定性，以探讨吸附蛋白质分子的结构是否可以得到稳定。
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