Department of Ophthalmology, Yeungnam University College of Medicine, #170 Hyunchungro, Nam-gu, Daegu, 42415, South Korea.
Yeungnam Eye Center, Yeungnam University Hospital, Daegu, South Korea.
Sci Rep. 2021 Jan 11;11(1):271. doi: 10.1038/s41598-020-79522-5.
We aimed to investigate the relationship between non-perfusion on ultra-widefield angiography (UWF FA) and aqueous cytokine levels and central macular thickness (CMT) in eyes with branch retinal vein occlusion (BRVO). Thirty-five eyes with treatment-naïve BRVO were included. Non-perfusion area (NPA) for partial and complete ischemia was manually segmented and the ischemic index (ISI) for each was calculated using stereographically projected UWF FA for four different retinal zones. Partial and complete ischemia had different regional predominance. Partial ischemia was predominant in the posterior regions, while complete ischemia was predominant in the periphery. And partial ischemic area, located posterior to far periphery, showed significant correlation with central macular thickness and concentrations of angiogenic and inflammatory cytokines, while complete ischemic area showed no correlation with any of the parameters. Taken together, partial but not complete ischemia, particularly in the more posterior retina, was associated with higher cytokine levels and more severe macular edema in eyes with BRVO. These findings would help us to better understand the different clinical significance of ischemia in BRVO depending on the severity and regional distribution.
我们旨在研究在未经治疗的视网膜分支静脉阻塞（BRVO）患者中，广角荧光血管造影（UWF FA）无灌注区与房水细胞因子水平和中心黄斑厚度（CMT）之间的关系。共纳入 35 只接受治疗的 BRVO 眼。使用立体投影 UWF FA 对四个不同视网膜区域手动分割部分和完全缺血的无灌注区（NPA），并计算每个区域的缺血指数（ISI）。部分和完全缺血具有不同的区域性优势。部分缺血主要位于后部区域，而完全缺血主要位于周边部。并且位于远周边部后部的部分缺血区与中央黄斑厚度和血管生成及炎症细胞因子浓度有显著相关性，而完全缺血区与任何参数均无相关性。综上所述，在 BRVO 眼中，部分而非完全缺血，特别是在后部更明显的缺血，与更高的细胞因子水平和更严重的黄斑水肿有关。这些发现将帮助我们更好地理解 BRVO 中缺血的不同临床意义，取决于其严重程度和区域分布。
