College of Nursing, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
College of Nursing, University of Kentucky, Lexington, USA.
Qual Life Res. 2021 Apr;30(4):1183-1190. doi: 10.1007/s11136-020-02725-w. Epub 2021 Jan 11.
The purpose of this study was to determine whether deficiencies of water-soluble vitamin intake predicted health-related quality of life (HRQOL) and the composite end point of all-cause mortality or cardiac- or heart failure (HF)-related hospitalization in HF patients. Patients with HF may be at risk for inadequate consumption of water-soluble vitamins due to poor appetite and dietary sodium restriction. Because water-soluble vitamins are important in metabolic processes, inadequate dietary intake of these vitamins may negatively affect health outcomes.
We consecutively recruited patients with HF from outpatient clinics affiliated with academic medical centers. Patients were referred by providers to investigators who verified their eligibility. Patients with HF completed a four-day food diary to determine dietary deficiencies of water-soluble vitamins and the Minnesota Living with HF questionnaire to assess HRQOL at baseline. Patients were followed to determine an event.
A total of 216 patients were included. Patients with a higher number of dietary deficiencies of water-soluble vitamins had poorer HRQOL (unstandardized coefficient = 4.92, 95% confidence interval 2.20-7.27). Cox regression showed that for each additional deficiency of a water-soluble vitamin intake, there was a 30% increase in risk for an event (95% confidence interval 1.03-1.75), controlling for demographic and clinical variables.
Inadequate dietary consumption of water-soluble vitamins was associated with poor HRQOL and prognosis and in HF. Our findings highlight that clinicians should understand the importance of encouraging patients to consume water-soluble vitamin-rich foods, which may result in enhancing outcomes in HF.
本研究旨在确定水溶性维生素摄入不足是否可预测心力衰竭（HF）患者的健康相关生活质量（HRQOL）以及全因死亡率或与心脏或心力衰竭（HF）相关的住院的复合终点。HF 患者由于食欲不佳和饮食钠限制，可能存在水溶性维生素摄入不足的风险。由于水溶性维生素在代谢过程中很重要，因此这些维生素的饮食摄入不足可能会对健康结果产生负面影响。
我们连续从学术医疗中心的门诊招募 HF 患者。患者由提供者推荐给研究人员，以确定其是否符合入组条件。HF 患者完成了为期四天的食物日记，以确定水溶性维生素的饮食缺乏情况，并在基线时使用明尼苏达州心力衰竭生活质量问卷评估 HRQOL。对患者进行随访以确定事件的发生。
共纳入 216 例患者。水溶性维生素饮食缺乏较多的患者 HRQOL 较差（未标准化系数=4.92，95%置信区间 2.20-7.27）。Cox 回归显示，每增加一种水溶性维生素摄入不足，事件风险增加 30%（95%置信区间 1.03-1.75），调整了人口统计学和临床变量。
HF 患者水溶性维生素饮食摄入不足与较差的 HRQOL 和预后相关。我们的研究结果强调，临床医生应了解鼓励患者食用富含水溶性维生素的食物的重要性，这可能会改善 HF 的结局。
