银屑治疗后持续性淋巴细胞减少症的病例系列。
A case series of persistent lymphopaenia following treatment with fumaric acid esters for psoriasis.
机构信息
Tallaght University Hospital, Dublin, Ireland.
Tallaght Hospital, Dublin, Ireland.
出版信息
J Clin Pharm Ther. 2021 Jun;46(3):859-861. doi: 10.1111/jcpt.13354. Epub 2021 Jan 11.
WHAT IS KNOWN AND OBJECTIVE
Fumaric acid esters (FAEs) have been used for fifty years to treat moderate-to-severe psoriasis. However, recent case reports of progressive multifocal leukoencephalopathy, associated with FAE-induced lymphopaenia, have been a cause for concern (J Dtsch Dermatol Ges. 2009;7:603).
CASE SERIES
We report six cases of persistent lymphopaenia following cessation of treatment with FAEs, with a mean duration of lymphopaenia of 33 months.
WHAT IS NEW AND CONCLUSION
Given the lack of evidence regarding expected recovery of lymphocyte counts, further research is required to guide physicians in the risk stratification of patients prior to considering treatment with FAEs.
已知和目的
富马酸酯（FAE）已被用于治疗中重度银屑病已有五十年。然而，最近有报道称，FAE 引起的淋巴细胞减少与进行性多灶性白质脑病有关，这引起了人们的关注（J Dtsch Dermatol Ges. 2009;7:603）。
病例系列
我们报告了六例 FAE 停药后持续的淋巴细胞减少症，平均淋巴细胞减少持续时间为 33 个月。
新内容和结论
鉴于关于淋巴细胞计数恢复预期的证据不足，需要进一步研究，以便在考虑使用 FAE 治疗之前，指导医生对患者进行风险分层。
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