Department of Biliary Surgery, West China Hospital of Sichuan University, No. 37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan, China.
J Mater Chem B. 2021 Jan 28;9(4):1138-1150. doi: 10.1039/d0tb02410d. Epub 2021 Jan 12.
Gold nanomaterials are widely used in biomedical research as drug delivery systems, imaging agents and therapeutic materials owing to their unique physicochemical properties and high biocompatibility. In this study, we prepared ultra-small gold nanoparticles (AuNPs) and induced them with gadolinium ions to form a spherical self-assembly. The nanoparticles were coupled with matrix metalloproteinase-2 (MMP-2) and loaded with the photosensitive drug IR820 for photothermal/photodynamic combination therapy of liver cancer. The formed nanoprobes were metabolised in vivo via degradation under dual-mode real-time imaging because of their acid response degradation characteristics. In addition, the nanoprobe showed excellent tumour-targeting ability due to the presence of surface-modified MMP-2. In vivo treatment experiments revealed that the nanoprobes achieved enhanced photodynamic/photothermal combination therapy under laser irradiation and significantly inhibited tumour growth. Therefore, the nanoprobes have great potential for anti-tumour therapy guided by dual-mode real-time imaging of liver cancer.
金纳米材料由于其独特的物理化学性质和高生物相容性，被广泛应用于生物医学研究中，作为药物传递系统、成像剂和治疗材料。在本研究中，我们制备了超小的金纳米粒子（AuNPs），并用镧系元素离子诱导它们形成球形自组装。这些纳米粒子与基质金属蛋白酶-2（MMP-2）偶联，并负载光敏感药物 IR820，用于肝癌的光热/光动力联合治疗。由于其酸响应降解特性，形成的纳米探针在体内通过双重模式实时成像进行代谢。此外，由于表面修饰的 MMP-2 的存在，纳米探针显示出优异的肿瘤靶向能力。体内治疗实验表明，纳米探针在激光照射下实现了增强的光动力/光热联合治疗，并显著抑制了肿瘤生长。因此，这些纳米探针在肝癌的双模式实时成像引导下具有很大的抗肿瘤治疗潜力。
