西咪替丁治疗胃溃疡患者：一项多中心对照试验。
Cimetidine in patients with gastric ulcer: a multicentre controlled trial.
作者信息
Frost F, Rahbek I, Rune S J, Jensen K B, Gudmand-Hoyer E, Krag E, Rask-Madsen J, Wulff H R, Garbol J, Jensen K G, Hojlund M, Nissen V R
出版信息
Br Med J. 1977 Sep 24;2(6090):795-7. doi: 10.1136/bmj.2.6090.795.
Abstract
Forty-five adult outpatients with endoscopically confirmed gastric ulceration completed a double-blind trial of either cimetidine (1 g/day) or placebo. After six weeks 18 of the 23 patients receiving cimetidine showed complete ulcer healing compared with only six of the 22 patients receiving placebo. The cimetidine group also had fewer days with pain than the placebo group but the difference was not statistically significant. Cimetidine therefore seems to promote healing of gastric ulcers without severe side effects, although its effect on pain is less pronounced than in patients with duodenal ulcers.
摘要
45例经内镜确诊为胃溃疡的成年门诊患者完成了一项关于西咪替丁（1克/天）或安慰剂的双盲试验。六周后，接受西咪替丁治疗的23例患者中有18例溃疡完全愈合，而接受安慰剂治疗的22例患者中只有6例完全愈合。西咪替丁组疼痛天数也比安慰剂组少，但差异无统计学意义。因此，西咪替丁似乎能促进胃溃疡愈合且无严重副作用，尽管其对疼痛的作用不如十二指肠溃疡患者明显。
相似文献
1
Cimetidine in patients with gastric ulcer: a multicentre controlled trial.西咪替丁治疗胃溃疡患者：一项多中心对照试验。
Br Med J. 1977 Sep 24;2(6090):795-7. doi: 10.1136/bmj.2.6090.795.
2
Cimetidine vs placebo in duodenal ulcer therapy. Six-week controlled double-blind investigation without any antacid therapy.西咪替丁与安慰剂治疗十二指肠溃疡的对比。为期六周的无任何抗酸剂治疗的对照双盲研究。
Dig Dis Sci. 1980 Oct;25(10):744-9. doi: 10.1007/BF01345292.
3
Cimetidine vs placebo: complete gastric ulcer pain relief. Six week controlled double blind study without any antacid therapy.西咪替丁与安慰剂对比：胃溃疡疼痛完全缓解。六周对照双盲研究，未进行任何抗酸治疗。
Acta Gastroenterol Latinoam. 1980;10(4):291-5.
4
[Therapy of duodenal and prepyloric ulcers with cimetidine (author's transl)].用西咪替丁治疗十二指肠溃疡和幽门前溃疡（作者译）
Wien Klin Wochenschr. 1979 Jan 19;91(2):53-7.
5
Cimetidine vs. placebo in prepyloric gastric ulcer therapy. Six week controlled double blind investigation without any antacid therapy.西咪替丁与安慰剂治疗幽门管胃溃疡的对比。六周对照双盲研究，不使用任何抗酸治疗。
Acta Gastroenterol Latinoam. 1980;10(3):199-202.
6
7
Effect of fifteen months of double-blind treatment with cimetidine and placebo on peptic ulcer recurrence.西咪替丁与安慰剂双盲治疗十五个月对消化性溃疡复发的影响。
Eur J Clin Pharmacol. 1981;19(5):335-41. doi: 10.1007/BF00544583.
8
Pirenzepine versus cimetidine in duodenal ulcer. A double-blind, placebo-controlled, short-term clinical trial.哌仑西平与西咪替丁治疗十二指肠溃疡的双盲、安慰剂对照短期临床试验
Digestion. 1982;23(2):110-5. doi: 10.1159/000198696.
9
Treatment of active duodenal ulcer with oral cimetidine: a multicenter controlled endoscopic trial.口服西咪替丁治疗活动性十二指肠溃疡：一项多中心对照内镜试验。
Digestion. 1978;17(5):383-6. doi: 10.1159/000198140.
10
Cimetidine in anastomotic ulceration after partial gastrectomy.西咪替丁与胃部分切除术后吻合口溃疡
Gastroenterology. 1979 Jul;77(1):83-5.
引用本文的文献
1
Putative auto-infarct of a pancreatic gastrinoma: a case report.胰腺胃泌素瘤疑似自发性梗死：一例报告
J Gastrointest Cancer. 2007;38(2-4):135-6. doi: 10.1007/s12029-008-9025-z.
2
Short-term treatment of gastric ulcer. A meta-analytical evaluation of blind trials.胃溃疡的短期治疗。盲法试验的荟萃分析评估。
Dig Dis Sci. 1996 Jun;41(6):1108-31. doi: 10.1007/BF02088227.
3
Effect of omeprazole and sucralfate on prepyloric gastric ulcer. A double blind comparative trial and one year follow up.奥美拉唑和硫糖铝对幽门前胃溃疡的作用。一项双盲对照试验及一年随访。
Gut. 1994 Jun;35(6):837-40. doi: 10.1136/gut.35.6.837.
4
Use of cimetidine in hospital patients.西咪替丁在住院患者中的应用。
Can Med Assoc J. 1981 Jun 15;124(12):1579-85.
5
Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy.西咪替丁与胃仙-U治疗胃溃疡的比较及后续维持治疗。
Gut. 1982 Jun;23(6):545-51. doi: 10.1136/gut.23.6.545.
6
The effect of cimetidine on the maintenance of healing of gastric ulceration.西咪替丁对胃溃疡愈合维持的影响。
Postgrad Med J. 1984 Oct;60(708):665-7. doi: 10.1136/pgmj.60.708.665.
7
Effect of cimetidine treatment in the prevention of gastric ulcer relapse: a one year double blind multicentre study.西咪替丁治疗预防胃溃疡复发的效果：一项为期一年的双盲多中心研究。
Gut. 1983 Sep;24(9):853-6. doi: 10.1136/gut.24.9.853.
8
Ranitidine in the prevention of gastric and duodenal ulcer relapse.雷尼替丁预防胃及十二指肠溃疡复发
Gut. 1983 May;24(5):418-20. doi: 10.1136/gut.24.5.418.
9
Healing of gastric ulcers after one, two, and three months of ranitidine.雷尼替丁治疗一、二、三个月后胃溃疡的愈合情况。
Br Med J (Clin Res Ed). 1982 Feb 13;284(6314):467-8. doi: 10.1136/bmj.284.6314.467.
10
Current therapy in peptic ulcer.消化性溃疡的当前治疗方法。
Drugs. 1980 Oct;20(4):283-99. doi: 10.2165/00003495-198020040-00003.
本文引用的文献
1
A pragmatic trial of cimetidine in duodenal ulcer patients.西咪替丁治疗十二指肠溃疡患者的一项实用试验。
Scand J Gastroenterol. 1977;12(5):611-3. doi: 10.3109/00365527709181342.
2
Cimetidine in the treatment of active duodenal and prepyloric ulcers.西咪替丁治疗活动性十二指肠溃疡和幽门前溃疡。
Lancet. 1976 Jul 24;2(7978):161-4. doi: 10.1016/s0140-6736(76)92342-4.
3
Oral cimetidine in severe duodenal ulceration. A double-blind controlled trial.西咪替丁口服治疗严重十二指肠溃疡。一项双盲对照试验。
Lancet. 1977 Jan 1;1(8001):4-7. doi: 10.1016/s0140-6736(77)91650-6.
Zotero 插件