西咪替丁治疗胃溃疡患者：一项多中心对照试验。
Cimetidine in patients with gastric ulcer: a multicentre controlled trial.
作者信息
Frost F, Rahbek I, Rune S J, Jensen K B, Gudmand-Hoyer E, Krag E, Rask-Madsen J, Wulff H R, Garbol J, Jensen K G, Hojlund M, Nissen V R
出版信息
Br Med J. 1977 Sep 24;2(6090):795-7. doi: 10.1136/bmj.2.6090.795.
Abstract
Forty-five adult outpatients with endoscopically confirmed gastric ulceration completed a double-blind trial of either cimetidine (1 g/day) or placebo. After six weeks 18 of the 23 patients receiving cimetidine showed complete ulcer healing compared with only six of the 22 patients receiving placebo. The cimetidine group also had fewer days with pain than the placebo group but the difference was not statistically significant. Cimetidine therefore seems to promote healing of gastric ulcers without severe side effects, although its effect on pain is less pronounced than in patients with duodenal ulcers.
摘要
45例经内镜确诊为胃溃疡的成年门诊患者完成了一项关于西咪替丁（1克/天）或安慰剂的双盲试验。六周后，接受西咪替丁治疗的23例患者中有18例溃疡完全愈合，而接受安慰剂治疗的22例患者中只有6例完全愈合。西咪替丁组疼痛天数也比安慰剂组少，但差异无统计学意义。因此，西咪替丁似乎能促进胃溃疡愈合且无严重副作用，尽管其对疼痛的作用不如十二指肠溃疡患者明显。
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本文引用的文献
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A pragmatic trial of cimetidine in duodenal ulcer patients.西咪替丁治疗十二指肠溃疡患者的一项实用试验。
Scand J Gastroenterol. 1977;12(5):611-3. doi: 10.3109/00365527709181342.
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Lancet. 1976 Jul 24;2(7978):161-4. doi: 10.1016/s0140-6736(76)92342-4.
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Oral cimetidine in severe duodenal ulceration. A double-blind controlled trial.西咪替丁口服治疗严重十二指肠溃疡。一项双盲对照试验。
Lancet. 1977 Jan 1;1(8001):4-7. doi: 10.1016/s0140-6736(77)91650-6.
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