Porro G B, Cheli R, Dobrillo G, Verme G, Molinari F, Pera A, Petrillo M, Valentini M
Digestion. 1978;17(5):383-6. doi: 10.1159/000198140.
A double-blind 4-week trial of cimetidine (1 g daily) versus placebo was conducted in 68 adult outpatients with active duodenal ulceration endoscopically confirmed. 3 of the patient admitted to the study (1 on cimetidine and 2 on placebo) did not complete the trial. After 4 weeks of treatment, 25 of 33 patients (76%) receiving cimetidine had healed their ulcers compared with 15 (47%) of 32 patients receiving placebo (p less than 0.02). Antacid consumption was also significantly decreased by cimetidine when compared with placebo. Tolerability of the drug was good.
对68例经内镜确诊为活动性十二指肠溃疡的成年门诊患者进行了一项为期4周的西咪替丁（每日1克）与安慰剂的双盲试验。3名入选该研究的患者（1名服用西咪替丁，2名服用安慰剂）未完成试验。治疗4周后，33名接受西咪替丁治疗的患者中有25名（76%）溃疡愈合，而32名接受安慰剂治疗的患者中有15名（47%）溃疡愈合（p<0.02）。与安慰剂相比，西咪替丁还显著减少了抗酸剂的用量。该药物的耐受性良好。
