Castro Marina, Pitino Michael A, Bando Nicole, Aufreiter Susanne, Stone Debbie, O'Connor Deborah L, Unger Sharon
Department of Pediatrics, Sinai Health, Toronto, Ontario, Canada.
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
JPEN J Parenter Enteral Nutr. 2021 Nov;45(8):1785-1787. doi: 10.1002/jpen.2073. Epub 2021 Mar 5.
When there is insufficient mother's milk for preterm infants, fortified human donor milk (DM) is the preferred supplement. Recently, there is growing interest in providing DM to term infants. Aside from vitamin D, mother's milk is a complete source of nutrition for term infants. It is unknown whether supplementation of micronutrients is required for term infants exclusively fed DM, particularly for nutrients affected by heat processing, such as vitamin C. The objective of this study was to determine the total vitamin C content in DM and whether it would be adequate for an infant exclusively fed DM.
DM samples (n = 56) were collected at a Canadian milk bank from April to August 2018. Vitamin C concentration was determined by high-performance liquid chromatography.
DM samples had a vitamin C concentration of 17.7 ± 9.8 mg/L (mean ± SD) and were variable, ranging from 1.9 to 43.2 mg/L. Using these values and assuming an exclusive DM consumption of 780 mL/day, the estimated vitamin C intake would be 13.8 ± 8.6 mg (mean ± SD), falling below the adequate intake of 40 mg/day for infants (0-6 months old).
Vitamin C supplementation is required for all infants if DM is the sole source of nutrition. Future studies should investigate other heat- and light-sensitive nutrients.
当早产儿的母乳不足时，强化人乳捐赠奶（DM）是首选的补充品。最近，给足月儿提供DM的兴趣日益增加。除了维生素D外，母乳是足月儿完整的营养来源。对于仅以DM为食的足月儿是否需要补充微量营养素尚不清楚，特别是对于受热处理影响的营养素，如维生素C。本研究的目的是确定DM中的总维生素C含量，以及它是否足以满足仅以DM为食的婴儿的需求。
2018年4月至8月在加拿大一家母乳库收集了DM样本（n = 56）。通过高效液相色谱法测定维生素C浓度。
DM样本的维生素C浓度为17.7±9.8mg/L（平均值±标准差），且各不相同，范围为1.9至43.2mg/L。使用这些值并假设每天仅食用780mL的DM，估计的维生素C摄入量为13.8±8.6mg（平均值±标准差），低于婴儿（0 - 6个月大）40mg/天的充足摄入量。
如果DM是唯一的营养来源，所有婴儿都需要补充维生素C。未来的研究应调查其他对热和光敏感的营养素。
