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基于精油的抗菌涂层。

Coatings Based on Essential Oils for Combating Antibiotic Resistance.

作者信息

Visan Anita Ioana, Negut Irina

机构信息

National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Ilfov, Romania.

出版信息

Antibiotics (Basel). 2024 Jul 4;13(7):625. doi: 10.3390/antibiotics13070625.

Abstract

In the current era of widespread antimicrobial resistance, the utilization of essential oils (EOs) derived from plants has emerged as a promising alternative in combating pathogens that have developed resistance to antibiotics. This review explores the therapeutic potential of essential oils as valuable tools in restoring the efficacy of antibiotics, highlighting their unique ability to affect bacteria in multiple ways and target various cellular systems. Despite the challenge of elucidating their precise mode of action, EOs have shown remarkable results in rigorous testing against a diverse range of bacteria. This review explores the multifaceted role of EOs in combating bacterial microorganisms, emphasizing their extraction methods, mechanisms of action, and comparative efficacy against synthetic antibiotics. Key findings underscore the unique strategies EOs deploy to counter bacteria, highlighting significant differences from conventional antibiotics. The review extends to advanced coating solutions for medical devices, exploring the integration of EO formulations into these coatings. Challenges in developing effective EO coatings are addressed, along with various innovative approaches for their implementation. An evaluation of these EO coatings reveals their potential as formidable alternatives to traditional antibacterial agents in medical device applications. This renaissance in exploring natural remedies emphasizes the need to combine traditional wisdom with modern scientific advancements to address the urgent need for effective antimicrobial solutions in the post-antibiotic era.

摘要

在当前抗菌药物广泛耐药的时代,利用植物源精油已成为对抗已对抗生素产生耐药性的病原体的一种有前景的替代方法。本综述探讨了精油作为恢复抗生素疗效的有价值工具的治疗潜力,强调了它们以多种方式影响细菌并靶向各种细胞系统的独特能力。尽管阐明其确切作用方式具有挑战性,但精油在针对多种细菌的严格测试中已显示出显著效果。本综述探讨了精油在对抗细菌微生物方面的多方面作用,强调了它们的提取方法、作用机制以及与合成抗生素相比的疗效。主要发现强调了精油对抗细菌所采用的独特策略,突出了与传统抗生素的显著差异。该综述扩展到医疗器械的先进涂层解决方案,探讨了将精油配方整合到这些涂层中的情况。讨论了开发有效的精油涂层所面临的挑战以及实施这些涂层的各种创新方法。对这些精油涂层的评估揭示了它们在医疗器械应用中作为传统抗菌剂的强大替代品的潜力。探索天然疗法的这一复兴强调了将传统智慧与现代科学进步相结合的必要性,以满足后抗生素时代对有效抗菌解决方案的迫切需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d54/11273621/db88c2966298/antibiotics-13-00625-g001.jpg

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