Towards Development of a Non-Intrusive and Label-Free THz Sensor for Rapid Detection of Aqueous Bio-Samples Using Microfluidic Approach.

As most of the bio-molecules sizes are comparable to the terahertz (THz) wavelength, this frequency range has spurred great attention for bio-medical and bio-sensing applications. Utilizing such capabilities of THz electromagnetic wave, this paper presents the design and analysis of a new non-intrusive and label-free THz bio-sensor for aqueous bio-samples using the microfluidic approach with real-time monitoring. The proposed THz sensor unit utilizes the highly confined feature of the localized spoof surface plasmon (LSSP) resonator to get high sensitivity for any minute change in the dielectric value near it's surface. The proposed sensor, which is designed at 1 THz, exploits the reflection behavior (S) of the LSSP resonator as the sensing response. The proposed sensor has been designed with a high-quality factor of 192 to obtain a high sensitivity of 13.5 MHz/mgml. To validate the proposed concept, a similar sensor unit has been designed and implemented at microwave frequency owing to the geometry dependent characteristics of the LSSP. The developed sensor has got a highly sensitive response at microwave frequency with a sensitivity of 1.2771e-4 MHz/mgml. A customized read-out circuitry is also designed and developed to get the sensor response in terms of DC-voltage and to provide a proof of concept for the low-cost point of care (PoC) detection solution using the proposed sensor. It is anticipated that the proposed design of highly sensitive sensor will pave a path to develop lab-on-chip systems for bio-sensing applications.