核因子 E4BP4 对肝脏代谢的调节。
Hepatic metabolic regulation by nuclear factor E4BP4.
机构信息
Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, China.
Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
出版信息
J Mol Endocrinol. 2021 Jan;66(1):R15-R21. doi: 10.1530/JME-20-0239.
Abstract
Discovered as a b-ZIP transcription repressor 30 years ago, E4 promoter-binding protein 4 (E4BP4) has been shown to play critical roles in immunity, circadian rhythms, and cancer progression. Recent research has highlighted E4BP4 as a novel regulator of metabolisms in various tissues. In this review, we focus on the function and mechanisms of hepatic E4BP4 in regulating lipid and glucose homeostasis, bile metabolism, as well as xenobiotic metabolism. Finally, E4BP4-specific targets will be discussed for the prevention and treatment of metabolic disorders.
摘要
30 年前，E4 启动子结合蛋白 4（E4BP4）被发现作为 b-ZIP 转录阻遏物，其在免疫、昼夜节律和癌症进展中发挥关键作用。最近的研究强调了 E4BP4 作为各种组织中代谢的新型调节剂。在这篇综述中，我们重点讨论了肝脏 E4BP4 调节脂质和葡萄糖稳态、胆汁代谢以及外源性代谢物代谢的功能和机制。最后，将讨论 E4BP4 的特异性靶标，以预防和治疗代谢紊乱。
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