Prien T, Traber D L, Richardson J A, Traber L D
Klinik für Anästhesiologie und operative Intensivmedizin, Westfälischen Wilhelms-Universität, Münster, FRG.
Intensive Care Med. 1988;14(1):25-9. doi: 10.1007/BF00254117.
We investigated the early effects of a rather large amount of cotton-smoke on lung mechanics and pulmonary perfusion. Under halothane anesthesia 18 ewes were intubated with a double-lumen tube. In 6 sheep the left lung was exposed to smoke, in another 6 the right lung. A sham group of 6 sheep was insufflated with air instead of smoke. Prior to and 30-45 min following the smoking- (sham-) procedure the following parameters were determined for the smoke- (sham-) exposed and the contralateral lung: static compliance, inspiratory airway resistance, and physiologic dead space ratio. In addition MAP, MPAP, WP, and CO were recorded. The data indicate that inhalation of large amounts of smoke has no major direct effects on pulmonary mechanics and perfusion in the early post-injury period. Only an increase in airway resistance of the smoke exposed lungs was found, which must be attributed to a local reflex mechanism.
我们研究了相当大量的棉烟对肺力学和肺灌注的早期影响。在氟烷麻醉下，给18只母羊插入双腔管。6只羊的左肺暴露于烟雾中，另外6只羊的右肺暴露于烟雾中。6只羊组成的假手术组用空气而非烟雾进行吹入。在吸烟（假手术）操作之前以及操作后30 - 45分钟，对暴露于烟雾（假手术）的肺和对侧肺测定以下参数：静态顺应性、吸气气道阻力和生理死腔率。此外，记录平均动脉压（MAP）、平均肺动脉压（MPAP）、楔压（WP）和心输出量（CO）。数据表明，吸入大量烟雾在损伤后早期对肺力学和灌注没有重大直接影响。仅发现暴露于烟雾的肺的气道阻力增加，这必定归因于局部反射机制。
