Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan; National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Cancer Cell. 2021 Jan 11;39(1):19-21. doi: 10.1016/j.ccell.2020.12.020.
Targeted protein degradation is an emerging technology for drug development. An article published in Nature reported a novel mechanism of targeted protein degradation triggered by small-molecule-induced polymerization of the oncogenic transcription factor BCL6.
靶向蛋白降解是一种新兴的药物研发技术。《自然》杂志上的一篇文章报道了一种新型的靶向蛋白降解机制，该机制是由致癌转录因子 BCL6 的小分子诱导聚合触发的。
