Department of Radiation Oncology, The First Hospital of Jilin University, Changchun 130021, China; Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China; Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun 130021, China.
Department of Orthopedic, The Second Hospital of Jilin University, Changchun, 130041, China.
Pharmacol Res. 2021 Mar;165:105420. doi: 10.1016/j.phrs.2021.105420. Epub 2021 Jan 9.
Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract. They are believed to be essential factors affecting host health. Most in vitro and ex vivo studies have shown that SCFAs affect the regulation of inflammation, carcinogenesis, intestinal barrier function, and oxidative stress, but convincing evidence in humans is still lacking. Two major SCFA signaling mechanisms have been identified: promotion of histone acetylation and activation of G-protein-coupled receptors. In this review, we introduce the production and metabolic characteristics of SCFAs, summarize the potential effects of SCFAs on the four aspects mentioned above and the possible mechanisms. SCFAs have been reported to exert a wide spectrum of positive effects and have a high potential for therapeutic use in human-related diseases.
短链脂肪酸（SCFAs）主要包括乙酸盐、丙酸盐和丁酸盐，是肠道中膳食纤维细菌发酵产生的代谢产物。它们被认为是影响宿主健康的重要因素。大多数体外和离体研究表明，SCFAs 影响炎症、癌变、肠道屏障功能和氧化应激的调节，但在人类中仍缺乏令人信服的证据。已经确定了两种主要的 SCFA 信号机制：促进组蛋白乙酰化和激活 G 蛋白偶联受体。在这篇综述中，我们介绍了 SCFAs 的产生和代谢特征，总结了 SCFAs 对上述四个方面的潜在影响及其可能的机制。据报道，SCFAs 具有广泛的积极作用，在人类相关疾病的治疗中有很高的应用潜力。
