MR1 限制性 T 细胞在感染、癌症和自身免疫性疾病中的新兴作用。
The burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease.
机构信息
Division of Infection and Immunity, Cardiff University School of Medicine, Henry Wellcome Building, University Hospital Wales, Cardiff CF14 4XN, Wales, UK.
Division of Infection and Immunity, Cardiff University School of Medicine, Henry Wellcome Building, University Hospital Wales, Cardiff CF14 4XN, Wales, UK; Systems Immunity Research Institute, Cardiff University, Cardiff CF10 3AT, Wales, UK.
出版信息
Curr Opin Immunol. 2021 Apr;69:10-17. doi: 10.1016/j.coi.2020.12.002. Epub 2021 Jan 9.
MR1 is a ubiquitously expressed, monomorphic antigen presenting molecule that has been largely preserved throughout mammalian evolution. The primary role of MR1 is to present conserved microbial metabolites to highly abundant mucosal-associated invariant T (MAIT) cells. The role of MAIT cells and other MR1-restricted T cells (MR1T) has been recently extended to immunomodulation during cancer. MR1Ts have also been implicated in autoimmune disease. The highly conserved nature of MR1 across the human population is in stark contrast to the MHC molecules recognised by conventional αβ T-cells, therefore MR1Ts may form fertile ground for the development of pan-population T-cell immunotherapeutics for a wide range of important morbidities.
MR1 是一种广泛表达的、单态的抗原呈递分子，在哺乳动物进化过程中得到了很大的保留。MR1 的主要作用是将保守的微生物代谢产物呈递给大量存在的粘膜相关不变 T（MAIT）细胞。MAIT 细胞和其他 MR1 限制性 T 细胞（MR1T）的作用最近已经扩展到癌症中的免疫调节。MR1T 也与自身免疫性疾病有关。MR1 在人类中的高度保守性与传统的 αβ T 细胞识别的 MHC 分子形成鲜明对比，因此 MR1T 可能为广泛的重要疾病的泛人群 T 细胞免疫治疗的发展提供肥沃的土壤。
Zotero 插件