Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2021 Mar;135:111256. doi: 10.1016/j.biopha.2021.111256. Epub 2021 Feb 1.
MicroRNA-140 (miR-140) has been shown to be associated with the pathogenesis of a wide range of pathologies including osteoarthritis, osteoporosis, renal fibrosis, ischemic conditions, and most importantly neoplasia. This miRNA has been shown to be down-regulated in a diversity of cancers namely breast cancer, gastrointestinal cancers, lung cancer, and prostate cancer. miR-140 has a lot of immune-related targets. Moreover, several miR-140 targets regulate cell proliferation, cell cycle transition, and apoptosis. This miRNA has been shown to be sponged by a number of lncRNAs and circ-RNAs. miR-140 has essential roles in the determination of the sensitivity of neoplastic cells to chemotherapeutic agents such as temozolomide, doxorubicin, and cisplatin. Besides, expression quantities of miR-140 in cancer tissues can be used for the prediction of clinical outcomes of patients with neoplasia. In the present paper, we describe the impact of miR-140 in neoplastic and non-neoplastic disorders.
微小 RNA-140（miR-140）已被证明与多种病理学的发病机制有关，包括骨关节炎、骨质疏松症、肾纤维化、缺血性疾病，最重要的是肿瘤发生。这种 miRNA 在多种癌症中表达下调，如乳腺癌、胃肠道癌症、肺癌和前列腺癌。miR-140 有许多与免疫相关的靶标。此外，一些 miR-140 靶标调节细胞增殖、细胞周期转换和细胞凋亡。已经证明许多长链非编码 RNA 和 circ-RNAs 能海绵吸附 miR-140。miR-140 在决定肿瘤细胞对替莫唑胺、阿霉素和顺铂等化疗药物的敏感性方面起着重要作用。此外，癌症组织中 miR-140 的表达量可用于预测肿瘤患者的临床预后。在本文中，我们描述了 miR-140 在肿瘤和非肿瘤性疾病中的作用。
