文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

癌症免疫治疗的新范式：靶向免疫原性细胞死亡相关非编码RNA

A new paradigm for cancer immunotherapy: targeting immunogenic cell death-related noncoding RNA.

作者信息

Sun Guojuan, He Ling

机构信息

The Ward Section of Home Overseas Doctors, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

Front Immunol. 2025 Jan 23;15:1498781. doi: 10.3389/fimmu.2024.1498781. eCollection 2024.

DOI:10.3389/fimmu.2024.1498781
PMID:39916954
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11798941/
Abstract

Cancer immunotherapy has shown significant potential in treating several malignancies by stimulating the host immune system to recognize and attack cancer cells. Immunogenic cell death (ICD) can amplify the antitumor immune responses and reverse the immunosuppressive tumor microenvironment, thus increasing the sensitivity of cancer immunotherapy. In recent years, noncoding RNAs (ncRNAs) have emerged as key regulatory factors in ICD and oncologic immunity. Accordingly, ICD-related ncRNAs hold promise as novel therapeutic targets for optimizing the efficacy of cancer immunotherapy. However, the immunomodulatory properties of ICD-related ncRNAs have not yet been comprehensively summarized. Hence, we summarize the current knowledge on ncRNAs involved in ICD and their potential roles in cancer immunotherapy in this review. It deepens our understanding of ncRNAs associated with ICD and provides a new strategy to enhance cancer immunotherapy by specifically targeting the ICD-related ncRNAs.

摘要

癌症免疫疗法通过刺激宿主免疫系统识别并攻击癌细胞，在治疗多种恶性肿瘤方面显示出巨大潜力。免疫原性细胞死亡（ICD）可增强抗肿瘤免疫反应并逆转免疫抑制性肿瘤微环境，从而提高癌症免疫疗法的敏感性。近年来，非编码RNA（ncRNAs）已成为ICD和肿瘤免疫中的关键调控因子。因此，与ICD相关的ncRNAs有望成为优化癌症免疫疗法疗效的新型治疗靶点。然而，与ICD相关的ncRNAs的免疫调节特性尚未得到全面总结。因此，在本综述中，我们总结了目前关于参与ICD的ncRNAs的知识及其在癌症免疫疗法中的潜在作用。这加深了我们对与ICD相关的ncRNAs的理解，并为通过特异性靶向与ICD相关的ncRNAs来增强癌症免疫疗法提供了新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e08/11798941/86a07ae0175f/fimmu-15-1498781-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e08/11798941/72af58e1ee3d/fimmu-15-1498781-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e08/11798941/b042b8737934/fimmu-15-1498781-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e08/11798941/cca8e243f6f7/fimmu-15-1498781-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e08/11798941/feb576c8538b/fimmu-15-1498781-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e08/11798941/86a07ae0175f/fimmu-15-1498781-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e08/11798941/72af58e1ee3d/fimmu-15-1498781-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e08/11798941/b042b8737934/fimmu-15-1498781-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e08/11798941/cca8e243f6f7/fimmu-15-1498781-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e08/11798941/feb576c8538b/fimmu-15-1498781-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e08/11798941/86a07ae0175f/fimmu-15-1498781-g005.jpg

相似文献

[1]
A new paradigm for cancer immunotherapy: targeting immunogenic cell death-related noncoding RNA.

Front Immunol. 2025-1-23

[2]
Recent Advances in Cancer Immunotherapy Aided by Regulatory Non-Coding RNA: A Review.

Asian Pac J Cancer Prev. 2025-6-1

[3]
Dietary impacts on prostate cancer immunotherapy.

Immunotherapy. 2025-5

[4]
Oncolytic reovirus enhances the effect of CEA immunotherapy when combined with PD1-PDL1 inhibitor in a colorectal cancer model.

Immunotherapy. 2025-4

[5]
Single cell RNA sequencing to identify an Immunogenic cell death related prognostic signature in intrahepatic cholangiocarcinoma.

Sci Rep. 2025-7-2

[6]
REGULATORY ROLE OF NONCODING RNA IN SEPSIS AND SEPSIS-ASSOCIATED ORGAN DYSFUNCTION: AN UPDATED SYSTEMATIC REVIEW.

Shock. 2022-11-1

[7]
Tumor microenvironment and immunotherapy: from bench to bedside.

Med Oncol. 2025-6-8

[8]
A novel approach to enhance glioblastoma multiforme treatment efficacy: non-coding RNA targeted therapy and adjuvant approaches.

Clin Epigenetics. 2025-6-21

[9]
Evaluation of antigen agnostic anti-tumor activity and immune memory induced by CBX-15 (alphalex-MMAE) in the rat.

Immunotherapy. 2025-5

[10]
Membrane-Coated Hollow Manganese Nitrogen Carbon Nanocomposites Synergize Phototherapy and STING Activation for Immunogenic Tumor Microenvironment Remodeling.

ACS Appl Mater Interfaces. 2025-6-25

引用本文的文献

[1]
Immunogenic Cell Death as a Target for Combination Therapies in Solid Tumors: A Systematic Review Toward a New Paradigm in Immuno-Oncology.

Cureus. 2025-6-11

本文引用的文献

[1]
Circular RNAs in tumor immunity and immunotherapy.

Mol Cancer. 2024-8-21

[2]
Unveiling the PDK4-centered rituximab-resistant mechanism in DLBCL: the potential of the "Smart" exosome nanoparticle therapy.

Mol Cancer. 2024-7-15

[3]
Emerging role of immunogenic cell death in cancer immunotherapy.

Front Immunol. 2024

[4]
Targeting immunogenic cell stress and death for cancer therapy.

Nat Rev Drug Discov. 2024-6

[5]
DAMPs and DAMP-sensing receptors in inflammation and diseases.

Immunity. 2024-4-9

[6]
miR-142-3p/5p role in cancer: From epigenetic regulation to immunomodulation.

Cell Biochem Funct. 2024-3

[7]
Prospects and challenges of noncoding-RNA-mediated inhibition of heat shock protein 90 for cancer therapy.

Biochim Biophys Acta Gene Regul Mech. 2024-3

[8]
Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides.

Nature. 2024-1

[9]
Mitochondrial DNA-triggered innate immune response: mechanisms and diseases.

Cell Mol Immunol. 2023-12

[10]
Prognostic value and immune landscapes of immunogenic cell death-associated lncRNAs in lung adenocarcinoma.

Sci Rep. 2023-11-6

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索