Xu Zhigang, Liu Shiying, Kang Yuejun, Wang Mingfeng
School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.
ACS Biomater Sci Eng. 2015 Jul 13;1(7):585-592. doi: 10.1021/acsbiomaterials.5b00119. Epub 2015 Jun 16.
This article presents a novel glutathione (GSH)-responsive poly(ethylene glycol)--polycarbonate--poly(ethylene glycol) triblock copolymer that self-assembles into micellar nanoparticles and simutaneously carry hydrophobic anticancer drugs such as doxirubicin. These drug-loading micelles show glutathione-triggered decomposition that leads to controlled drug release and cytotoxicity to cancer cells. This polymeric drug-carrier system integrates features of facile synthesis, stimuli-responsive drug release, good biocompatibility, and relatively low toxicity of the dissociated segments, thus representing a promising anticancer drug carrier for potential clinical applications.
本文介绍了一种新型的谷胱甘肽（GSH）响应性聚（乙二醇）-聚碳酸酯-聚（乙二醇）三嵌段共聚物，该共聚物自组装成胶束纳米颗粒，并同时携带阿霉素等疏水性抗癌药物。这些载药胶束表现出谷胱甘肽触发的分解，从而导致药物的可控释放和对癌细胞的细胞毒性。这种聚合物药物载体系统整合了合成简便、刺激响应性药物释放、良好的生物相容性以及解离片段相对较低的毒性等特点，因此是一种有前景的抗癌药物载体，具有潜在的临床应用价值。
