双响应二硫键聚多巴胺包覆的多孔 CeO 纳米棒用于靶向协同递药。

Dual-responsive dithio-polydopamine coated porous CeO nanorods for targeted and synergistic drug delivery.

机构信息

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.

Center for Applied Chemical Research, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China.

出版信息

Int J Nanomedicine. 2018 Apr 12;13:2161-2173. doi: 10.2147/IJN.S152002. eCollection 2018.

OBJECTIVE

The aim was to produce the first report of assembling degradable stimuli-responsive dithio-polydopamine coating with a cancer target unit for synergistic and targeted drug delivery.

METHODS

A multifunctional drug delivery system was constructed by coating a dual-responsive dithio-polydopamine (PDS) on porous CeO nanorods and subsequent conjugation of lactose derivative, where the PDS was formed by self-polymerization of dithio-dopamine (DOPASS).

RESULTS

The multifunctional drug delivery system displayed excellent cancer targeted ability resulting from the conjugation of lactose derivative, which could specifically recognize the overexpressed asialoglycoprotein receptors on the surface of HepG2 cells. It also showed a dual-responsive property of glutathione and pH, achieving controllable drug release from the cleavage of disulfide bond and subsequent degradation of PDS in cancer cells. Moreover, the degradation of PDS led to the exposure of CeO nanorods, which has a synergistic anticancer effect due to its cytotoxicity to cancer cells.

CONCLUSION

This work presents a good example of a rational design towards synergistic and targeted DDS for cancer chemotherapies.

目的

旨在首次报告组装具有癌症靶向单元的可降解刺激响应二硫键聚多巴胺涂层，用于协同和靶向药物递送。

方法

通过在多孔 CeO 纳米棒上涂覆双响应二硫键聚多巴胺（PDS）并随后缀合乳糖衍生物来构建多功能药物递送系统，其中 PDS 是由二硫键多巴胺（DOPASS）自聚合形成的。

结果

多功能药物递送系统由于缀合了乳糖衍生物而表现出优异的癌症靶向能力，该衍生物能够特异性识别 HepG2 细胞表面过表达的唾液酸糖蛋白受体。它还表现出谷胱甘肽和 pH 的双重响应特性，通过二硫键的裂解实现了药物的可控释放，随后 PDS 在癌细胞中的降解。此外，PDS 的降解导致 CeO 纳米棒的暴露，由于其对癌细胞的细胞毒性，因此具有协同的抗癌作用。