Goodfriend Amy C, Welch Tre R, Nguyen Kytai T, Wang Jian, Johnson Romaine F, Nugent Alan, Forbess Joseph M
Department of Bioengineering, University of Texas Arlington, Arlington, Texas 76019, United States.
ACS Biomater Sci Eng. 2015 Aug 10;1(8):677-684. doi: 10.1021/acsbiomaterials.5b00091. Epub 2015 Jun 30.
Bioresorbable medical devices once implanted into the body are "invisible" to imaging techniques such as X-ray/fluoroscopy and magnetic resonance imagining (MRI). Prior attempts to produce radiopaque polymers have limited success due to their inability to generate homogeneous mixtures of polymer and contrast agent without subsequent alterations in polymer structure. Here we investigate a novel approach in which a MRI contrast medium, gadodiamide, can be used as a polymerization initiator in poly(propylene fumarate) (PPF) synthesis to achieve a radiopaque and MRI-visible polymer poly(gadodiamide fumaric acid) (PGFA). With this method polymer structure, thermal properties, and rheological behavior are conserved with no prior manipulation to monomer units necessary. This unique polymer in combination with poly(lactic--glycolic acid) (PLGA) can be formulated into MRI-visible nanoparticles with drug delivery potential. This novel polymer in both liquid and nanoparticle form enables new possibilities in medical device and drug delivery design.
一旦植入体内，生物可吸收医疗设备对于诸如X射线/荧光透视和磁共振成像（MRI）等成像技术来说是“不可见的”。此前生产不透射线聚合物的尝试成效有限，因为它们无法在不改变聚合物结构的情况下生成聚合物与造影剂的均匀混合物。在此，我们研究了一种新方法，即磁共振成像造影剂钆双胺可在聚富马酸丙二醇酯（PPF）合成中用作聚合引发剂，以获得不透射线且能被MRI检测到的聚合物聚（钆双胺富马酸）（PGFA）。通过这种方法，聚合物结构、热性能和流变行为得以保留，无需对单体单元进行预先处理。这种独特的聚合物与聚乳酸-乙醇酸共聚物（PLGA）结合，可制成具有药物递送潜力且能被MRI检测到的纳米颗粒。这种新型聚合物的液体和纳米颗粒形式为医疗设备和药物递送设计带来了新的可能性。
