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多孔形状记忆聚合物的化学修饰以增强 X 射线和 MRI 可视性。

Chemical Modifications of Porous Shape Memory Polymers for Enhanced X-ray and MRI Visibility.

机构信息

Texas A&M University Biomedical Engineering, Bizzell St, College Station, TX 77843, USA.

Shape Memory Medical Inc., Santa Clara, CA 95054, USA.

出版信息

Molecules. 2020 Oct 13;25(20):4660. doi: 10.3390/molecules25204660.

DOI:10.3390/molecules25204660
PMID:33066091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7587375/
Abstract

The goal of this work was to develop a shape memory polymer (SMP) foam with visibility under both X-ray and magnetic resonance imaging (MRI) modalities. A porous polymeric material with these properties is desirable in medical device development for applications requiring thermoresponsive tissue scaffolds with clinical imaging capabilities. Dual modality visibility was achieved by chemically incorporating monomers with X-ray visible iodine-motifs and MRI visible monomers with gadolinium content. Physical and thermomechanical characterization showed the effect of increased gadopentetic acid (GPA) on shape memory behavior. Multiple compositions showed brightening effects in pilot, T-weighted MR imaging. There was a correlation between the polymeric density and X-ray visibility on expanded and compressed SMP foams. Additionally, extractions and indirect cytocompatibility studies were performed to address toxicity concerns of gadolinium-based contrast agents (GBCAs). This material platform has the potential to be used in a variety of medical devices.

摘要

这项工作的目标是开发一种在 X 射线和磁共振成像（MRI）两种模式下都具有可见性的形状记忆聚合物（SMP）泡沫。在医疗设备开发中，具有这些特性的多孔聚合物材料是理想的，适用于需要具有临床成像功能的热响应组织支架的应用。通过化学方式掺入具有 X 射线可见碘基序的单体和具有钆含量的 MRI 可见单体，实现了双重模式可见性。物理和热机械特性表明，增加钆喷替酸（GPA）对形状记忆行为有影响。多种成分在试点 T 加权磁共振成像中显示出增亮效果。膨胀和压缩的 SMP 泡沫的聚合物密度与 X 射线可见度之间存在相关性。此外，还进行了提取和间接细胞相容性研究，以解决基于钆的造影剂（GBCA）的毒性问题。该材料平台具有在各种医疗设备中应用的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/665369e55164/molecules-25-04660-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/aab546051952/molecules-25-04660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/b5eef12211f2/molecules-25-04660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/19719621218e/molecules-25-04660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/1bcefc5290b8/molecules-25-04660-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/447a1159486d/molecules-25-04660-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/e46ef70169e5/molecules-25-04660-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/fc5984f87088/molecules-25-04660-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/665369e55164/molecules-25-04660-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/aab546051952/molecules-25-04660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/b5eef12211f2/molecules-25-04660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/19719621218e/molecules-25-04660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/1bcefc5290b8/molecules-25-04660-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/447a1159486d/molecules-25-04660-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/e46ef70169e5/molecules-25-04660-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/fc5984f87088/molecules-25-04660-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/7587375/665369e55164/molecules-25-04660-g008.jpg

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本文引用的文献

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Iodinated Polyesters with Enhanced X-ray Contrast Properties for Biomedical Imaging.具有增强 X 射线对比性能的碘代聚酯在生物医学成像中的应用。
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Increased X-ray Visualization of Shape Memory Polymer Foams by Chemical Incorporation of Iodine Motifs.
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4
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