Cariati Ida, Bonanni Roberto, Pallone Gabriele, Annino Giuseppe, Tancredi Virginia, D'Arcangelo Giovanna
Department of Clinical Sciences and Translational Medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
Department of Systems Medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
Brain Sci. 2021 Jan 10;11(1):82. doi: 10.3390/brainsci11010082.
In the past 40 years, scientific research has shown how Whole Body Vibration concept represents a strong stimulus for the whole organism. Low (<30 Hz), medium (30-80 Hz), and high (>80 Hz) frequency vibrations can have both positive and negative effects, depending on the oscillation type and duration of exposure to which the body is subjected. However, very little is known about the effects of vibratory training on the brain. In this regard, we verified whether three vibratory training protocols, differing in terms of vibration frequency and exposure time to vibration, could modulate synaptic plasticity in an experimental mouse model, by extracellular recordings in vitro in hippocampal slices of mice of 4 and 24 months old. Our results showed that vibratory training can modulate synaptic plasticity differently, depending on the protocol used, and that the best effects are related to the training protocol characterized by a low vibration frequency and a longer recovery time. Future studies will aim to understand the brain responses to various types of vibratory training and to explore the underlying mechanisms, also evaluating the presence of any structural and functional changes due to vibratory training.
在过去40年里，科学研究表明全身振动概念对整个机体是一种强烈刺激。低（<30赫兹）、中（30 - 80赫兹）和高（>80赫兹）频率振动可能产生正面和负面效应，这取决于机体所遭受的振荡类型和暴露持续时间。然而，关于振动训练对大脑的影响却知之甚少。在这方面，我们通过对4个月和24个月大的小鼠海马切片进行体外细胞外记录，验证了三种在振动频率和振动暴露时间方面不同的振动训练方案是否能在实验小鼠模型中调节突触可塑性。我们的结果表明，振动训练可以根据所使用的方案不同地调节突触可塑性，并且最佳效果与以低振动频率和较长恢复时间为特征的训练方案相关。未来的研究旨在了解大脑对各种类型振动训练的反应，探索潜在机制，同时评估由于振动训练导致的任何结构和功能变化的存在情况。
