Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt am Main, Germany.
German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.
Cells. 2021 Jan 10;10(1):117. doi: 10.3390/cells10010117.
Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing on molecular pathways relating to signaling, metabolism and the bone marrow microenvironment. We highlight current strategies for combination therapies aimed at eradicating the CML stem cell; hopefully the final destination of this long voyage.
慢性髓细胞白血病（CML）是一种具有悠久历史的“模式疾病”。从最初发现白血病和描述费城染色体，到目前靶向治疗后实现无治疗缓解的目标，我们在这里描述 CML 的发展历程，重点介绍与信号转导、代谢和骨髓微环境相关的分子途径。我们强调了旨在根除 CML 干细胞的联合治疗的当前策略；希望这一漫长航程的最终目的地。
