Ghanemi Abdelaziz, Yoshioka Mayumi, St-Amand Jonny
Department of Molecular Medicine, Faculty of Medicine, Laval University, Québec, QC G1V 0A6, Canada.
Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Québec, QC G1V 4G2, Canada.
Life (Basel). 2021 Jan 8;11(1):38. doi: 10.3390/life11010038.
Diverse pathologies (inflammation, tissues injuries, cancer, etc.) and physiological conditions (obesity, physical activity, etc.) induce the expression/secretion of the matricellular protein, secrete protein acidic and rich in cysteine (SPARC). SPARC contributes to the creation of an environment that is suitable for tissue regeneration through a variety of roles, including metabolic homeostasis, inflammation reduction, extracellular matrix remodeling and collagen maturation. Such a homeostatic environment optimizes tissue regeneration and improves tissues' repair ability. These properties that SPARC has within the regeneration contexts could have a variety of applications, such as in obesity, cancer, sarcopenia, diabetes and bioengineering.
多种病理状况（炎症、组织损伤、癌症等）和生理状况（肥胖、体育活动等）会诱导基质细胞蛋白——富含半胱氨酸的酸性分泌蛋白（SPARC）的表达/分泌。SPARC通过多种作用，包括代谢稳态、减轻炎症、细胞外基质重塑和胶原蛋白成熟，有助于创造一个适合组织再生的环境。这样一个稳态环境可优化组织再生并提高组织的修复能力。SPARC在再生环境中的这些特性可能有多种应用，例如在肥胖、癌症、肌肉减少症、糖尿病和生物工程领域。
