Ghanemi Abdelaziz, Yoshioka Mayumi, St-Amand Jonny
Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Quebec, QC G1V 4G2, Canada.
Faculty of Pharmacy, Laval University, Quebec, QC G1V 0A6, Canada.
Biomedicines. 2025 Apr 12;13(4):945. doi: 10.3390/biomedicines13040945.
Exploring biological properties leading to potential pharmacological applications has been a fruitful approach in biomedical research. Secreted protein acidic and rich in cysteine (SPARC) is an exercise-induced glycoprotein known for its functions at different cellular and molecular levels. Among the properties it has, its calcium and collagen binding patterns along with other biochemical, metabolic, and structural effects represent a starting point towards developing therapeutic options based on SPARC properties for bones in pathological, preventive, and regenerative contexts. Such properties can be explored in conditions including bone fractures or requiring bone regenerative adjuvants. In addition, these properties can also be applied in basic research such as building an environment more suitable for cellular proliferation or optimizing in vitro conditions.
探索具有潜在药理学应用价值的生物学特性一直是生物医学研究中富有成效的方法。分泌性酸性富含半胱氨酸蛋白（SPARC）是一种运动诱导的糖蛋白，因其在不同细胞和分子水平上的功能而闻名。在其具有的特性中，它的钙和胶原蛋白结合模式以及其他生化、代谢和结构效应为基于SPARC特性开发针对病理、预防和再生背景下骨骼的治疗方案提供了一个起点。这些特性可以在包括骨折或需要骨再生佐剂的情况下进行探索。此外，这些特性还可应用于基础研究，如构建更适合细胞增殖的环境或优化体外条件。
