Exploring biological properties leading to potential pharmacological applications has been a fruitful approach in biomedical research. Secreted protein acidic and rich in cysteine (SPARC) is an exercise-induced glycoprotein known for its functions at different cellular and molecular levels. Among the properties it has, its calcium and collagen binding patterns along with other biochemical, metabolic, and structural effects represent a starting point towards developing therapeutic options based on SPARC properties for bones in pathological, preventive, and regenerative contexts. Such properties can be explored in conditions including bone fractures or requiring bone regenerative adjuvants. In addition, these properties can also be applied in basic research such as building an environment more suitable for cellular proliferation or optimizing in vitro conditions.