Pediatric, Nephrology and Allergology Clinic, Military Institute of Medicine, 04-141 Warsaw, Poland.
Laboratory of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), 04-141 Warsaw, Poland.
Nutrients. 2021 Jan 8;13(1):177. doi: 10.3390/nu13010177.
Vitamin D, in addition to its superior role as a factor regulating calcium-phosphate metabolism, shows wide effects in other processes in the human body, including key functions of the immune system. This is due to the presence of vitamin D receptors in most cells of the human body. In our study, we aimed to assess whether there is a correlation between vitamin D content and the clinical course of allergic diseases as well as establish their immunological parameters in children. We found that vitamin D deficiency was significantly more frequent in the group of children with an allergic disease than in the control group ( = 0.007). Statistically significant higher vitamin D concentrations in blood were observed in the group of children with a mild course of the disease compared to children with a severe clinical course ( = 0.03). In the group of children with vitamin D deficiency, statistically significant lower percentages of NKT lymphocytes and T-regulatory lymphocytes were detected compared to the group of children without deficiency (respectively, = 0.02 and = 0.05), which highlights a potential weakness of the immune system in these patients. Furthermore, statistically higher levels of interleukin-22 were observed in the group of children with vitamin D deficiency ( = 0.01), suggesting a proinflammatory alert state. In conclusion, these results confirm the positive relationship between the optimal content of vitamin D and the lesser severity of allergic diseases in children, establishing weak points in the immune system caused by vitamin D deficiency in children.
维生素 D 除了作为调节钙磷代谢的重要因素外，在人体的其他过程中也表现出广泛的作用，包括免疫系统的关键功能。这是由于维生素 D 受体存在于人体大多数细胞中。在我们的研究中，我们旨在评估维生素 D 含量与过敏性疾病的临床病程之间是否存在相关性，并确定儿童的免疫参数。我们发现，患有过敏性疾病的儿童组维生素 D 缺乏的发生率明显高于对照组（=0.007）。与患有严重临床病程的儿童相比，患有轻度疾病的儿童血液中的维生素 D 浓度显著升高（=0.03）。在维生素 D 缺乏的儿童组中，与不缺乏的儿童组相比，检测到 NKT 淋巴细胞和 T 调节性淋巴细胞的百分比显著降低（分别为=0.02 和=0.05），这突出了这些患者免疫系统的潜在弱点。此外，在维生素 D 缺乏的儿童组中观察到白细胞介素-22 的水平显著升高（=0.01），提示存在促炎警报状态。总之，这些结果证实了维生素 D 含量最佳与儿童过敏性疾病严重程度较低之间的正相关关系，确定了儿童维生素 D 缺乏引起的免疫系统薄弱点。
