Unit of Endocrinology, Centro Diagnostico Priamar, Savona, Italy -
Unit of Endocrinology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy -
Minerva Endocrinol (Torino). 2023 Mar;48(1):19-26. doi: 10.23736/S2724-6507.20.03312-X. Epub 2021 Jan 12.
Ultrasonography (US) is the simplest method of evaluating thyroid volume (TV). The current normal TV in Liguria is not known. The aim of this study was to obtain normative data on TV in Liguria, Italy.
From 3552 files of endocrine evaluations registered in a primary outpatient setting, we selected 483 files on euthyroid subjects (383 females and 100 males) with a normal echoic pattern on US. The inclusion criterion was the absence of thyroperoxidase autoantibodies and drugs known to interfere with thyroid hormone secretion or metabolism. TV was calculated by means of US. Anthropometric characteristics, smoking habits and the district where subjects lived were registered.
Less than 50% of patients were not taking any drug. The percentage of obesity was similar in both sexes. TSH levels were similar in males and females. Median TV was 8.0 mL (IQR: 6.7-9.8 mL) in females and 11.8 mL (9.3-15.6 mL) in males (P<0.0001). In females, TV was greater (P=0.01) in smokers than in non-smokers. In both sexes, the right lobe was significantly (P<0.0001) larger in volume than the left. Post-hoc analysis did not show any differences among age-groups in either females or males. In females, but not in males, TV differed significantly (P=0.0002) according to the district of residence. A significant positive correlation was found in both groups between TV and weight, height, BMI and BSA.
Reference values of TV in the Ligurian population are now available. TV in the general population could be compared with these normative data.
超声检查（US）是评估甲状腺体积（TV）的最简单方法。目前尚不清楚意大利利古里亚地区的正常 TV 值。本研究旨在获得意大利利古里亚地区的 TV 正常值数据。
从在初级门诊环境中登记的 3552 份内分泌评估文件中，我们选择了 483 份甲状腺功能正常的文件（383 名女性和 100 名男性），这些文件的 US 回声模式正常。纳入标准为无甲状腺过氧化物酶自身抗体以及已知会干扰甲状腺激素分泌或代谢的药物。通过 US 计算 TV。记录了人体测量特征、吸烟习惯和受试者居住的地区。
不到 50%的患者未服用任何药物。男女肥胖率相似。男性和女性的 TSH 水平相似。女性的 TV 中位数为 8.0 mL（IQR：6.7-9.8 mL），男性为 11.8 mL（9.3-15.6 mL）（P<0.0001）。在女性中，吸烟者的 TV 大于非吸烟者（P=0.01）。在男女中，右叶的体积明显大于左叶（P<0.0001）。事后分析显示，无论是女性还是男性，各年龄组之间的 TV 均无差异。在女性中，但在男性中，根据居住地区，TV 存在显著差异（P=0.0002）。在两组中，均发现 TV 与体重、身高、BMI 和 BSA 之间存在显著正相关。
现在有了利古里亚地区 TV 的参考值。可以将普通人群的 TV 与这些正常值进行比较。
