Zhang Wenchao, Qi Lin, Chen Ruiqi, He Jieyu, Liu Zhongyue, Wang Wanchun, Tu Chao, Li Zhihong
Department of Orthopedics, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, P.R. China.
Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, P.R. China.
Arthritis Res Ther. 2021 Jan 12;23(1):23. doi: 10.1186/s13075-021-02420-2.
Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked intensive interest. Initially considered as the transcriptional noises, further studies have indicated that circRNAs are crucial regulators in multiple cellular biological processes, and thus engage in the development and progression of many diseases including osteoarthritis (OA). OA is a prevalent disease that mainly affects those aging, obese and post-traumatic population, posing as a major source of socioeconomic burden. Recently, numerous circRNAs have been found aberrantly expressed in OA tissues compared with counterparts. More importantly, circRNAs have been demonstrated to interplay with components in OA microenvironments, such as chondrocytes, synoviocytes and macrophages, by regulation of their proliferation, apoptosis, autophagy, inflammation, or extracellular matrix reorganization. Herein, in this review, we extensively summarize the roles of circRNAs in OA microenvironment, progression, and putative treatment, as well as envision the future directions for circRNAs research in OA, with the aim to provide a novel insight into this field.
在过去几十年中，环状RNA（circRNAs）已成为一个热点并引发了广泛关注。最初被认为是转录噪音，进一步研究表明，circRNAs是多种细胞生物学过程中的关键调节因子，因此参与包括骨关节炎（OA）在内的许多疾病的发生和发展。OA是一种常见疾病，主要影响老年人、肥胖者和创伤后人群，是社会经济负担的主要来源。最近，与正常组织相比，在OA组织中发现了大量异常表达的circRNAs。更重要的是，circRNAs已被证明通过调节软骨细胞、滑膜细胞和巨噬细胞等OA微环境中的成分的增殖、凋亡、自噬、炎症或细胞外基质重组，与它们相互作用。在此综述中，我们广泛总结了circRNAs在OA微环境、进展和潜在治疗中的作用，并展望了OA中circRNAs研究的未来方向，旨在为该领域提供新的见解。
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