Wang Xiaoxiao, Zhang Chao, Song Huangqin, Yuan Junlong, Zhang Lei, He Jiefeng
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Department of Hepatobiliary Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Front Oncol. 2023 Jan 9;12:1061007. doi: 10.3389/fonc.2022.1061007. eCollection 2022.
Circular RNAs (circRNAs) are endogenous non-coding RNAs (ncRNAs) with a closed-loop structure. In recent years, circRNAs have become the focus of much research into RNA. CircCCDC66 has been identified as a novel oncogenic circRNA and is up-regulated in a variety of malignant tumors including thyroid cancer, non-small cell carcinoma, gastric cancer, colorectal cancer, renal cancer, cervical cancer, glioma, and osteosarcoma. It mediates cancer progression by regulating epigenetic modifications, variable splicing, transcription, and protein translation. The oncogenicity of circCCDC66 suppresses or promotes the expression of related genes mainly through direct or indirect pathways. This finding suggests that circCCDC66 is a biomarker for cancer diagnosis, prognosis assessment and treatment. However, there is no review on the relationship between circCCDC66 and cancers. Thus, the expression, biological functions, and regulatory mechanisms of circCCDC66 in malignant tumor and non-tumor diseases are summarized. The clinical value and prognostic significance of circCCDC66 are also evaluated, which can provide insights helpful to those exploring new strategies for the early diagnosis and targeted treatment of malignancies.
环状RNA（circRNAs）是一类具有闭环结构的内源性非编码RNA（ncRNAs）。近年来，circRNAs已成为RNA研究的热点。CircCCDC66已被鉴定为一种新型致癌circRNA，在包括甲状腺癌、非小细胞癌、胃癌、结直肠癌、肾癌、宫颈癌、胶质瘤和骨肉瘤在内的多种恶性肿瘤中上调。它通过调节表观遗传修饰、可变剪接、转录和蛋白质翻译来介导癌症进展。CircCCDC66的致癌性主要通过直接或间接途径抑制或促进相关基因的表达。这一发现表明circCCDC66是癌症诊断、预后评估和治疗的生物标志物。然而，目前尚无关于circCCDC66与癌症关系的综述。因此，本文总结了circCCDC66在恶性肿瘤和非肿瘤疾病中的表达、生物学功能及调控机制。同时也评估了circCCDC66的临床价值和预后意义，这可为探索恶性肿瘤早期诊断和靶向治疗新策略的研究提供有益的见解。
