Laboratoire Cognitions Humaine et Artificielle, École Pratique des Hautes Etudes, Paris, France.
CESP, Univ. Paris-Sud, UVSQ, INSERM U 1178, Université Paris-Saclay, 94805, Villejuif, France.
Sci Rep. 2021 Jan 12;11(1):771. doi: 10.1038/s41598-020-79410-y.
The interweaving of malnutrition and symptoms of anxiety and depression in anorexia Nervosa (AN) is mentioned without any consensus regarding the course of anxious-depressive symptoms in relation to nutritional status in the course of treatment of patients with AN. The objectives of the current study in a large sample of AN inpatients were to assess the relationships between anxiety and depression symptoms and nutritional status both over the course of inpatient treatment and at discharge. 222 consecutive inpatients with AN (DSM-IV TR) were assessed (entrance and discharge) for duration of illness, psychiatric treatments, sociodemographic data and with psychometric scales for different psychopathological symptoms [depressive (BDI), anxiety and depressive (HAD scale), obsessive-compulsive (MOCI) and social phobia (LSAS fear score)]. Nutritional status was assessed with Body Mass Index (BMI) and body composition by bioelectrical impedance. The Fat free mass index [FFMI = FFM (kg)/height (m)] was considered for the analysis. Two models were developed where the dependent variables were each psychopathological score at discharge (BDI, HAD anxiety, MOCI, and LSAS fear) in the cross-sectional model, and their variation in the longitudinal model (where a positive score reflected symptom decrease at discharge). A fixed set of predictors, defined on presumed clinical and statistical relevance (FFMI in the cross-sectional model and Variation of FFMI in the longitudinal model), were considered in each model, without any model selection procedure. This is the first study to confirm a positive relationship between the course of eating disorder symptoms and that of anxious-depressive symptoms during inpatient treatment of AN even after adjustment on a vast array of possibly confounding factors.
神经性厌食症（AN）中营养不良与焦虑和抑郁症状的交织现象被提及，但关于 AN 患者治疗过程中营养状况与焦虑抑郁症状的关系，目前尚无共识。本研究的目的是在 AN 住院患者的大样本中评估焦虑和抑郁症状与营养状况在住院治疗过程中的关系。连续 222 例 AN（DSM-IV TR）住院患者（入院时和出院时）进行了疾病持续时间、精神科治疗、社会人口统计学数据以及不同精神病理症状（抑郁[BDI]、焦虑和抑郁[HAD 量表]、强迫[MOCI]和社交恐惧症[LSAS 恐惧评分]）的心理计量评估。营养状况通过生物电阻抗法评估体重指数（BMI）和身体成分。考虑到无脂肪质量指数[FFMI=FFM（kg）/身高（m）]用于分析。在横断面模型中，依赖变量是每个出院时的精神病理评分（BDI、HAD 焦虑、MOCI 和 LSAS 恐惧），在纵向模型中是它们的变化（阳性分数反映了出院时症状的减少）。在每个模型中，考虑了一组固定的预测因子，这些预测因子是基于假定的临床和统计学相关性（横断面模型中的 FFMI 和纵向模型中的 FFMI 变化），而无需任何模型选择程序。这是第一项研究，即使在调整了大量可能的混杂因素后，也证实了 AN 住院治疗期间进食障碍症状的进展与焦虑抑郁症状的进展之间存在正相关关系。
