Division of Mental Health and Addiction, Regional Department for Eating Disorders, Oslo University Hospital Ullevål HF, Norway.
Int J Eat Disord. 2013 Sep;46(6):576-81. doi: 10.1002/eat.22155. Epub 2013 Jul 5.
To investigate neuropsychological functioning in adolescents with anorexia nervosa (AN) before and after receiving cognitive remediation therapy (CRT).
Twenty young females with AN participated in an individually-delivered CRT treatment program. Neuropsychological and psychiatric assessments were administered before and after treatment. Weight, depression, anxiety, duration of illness, and level of eating disorder psychopathology were considered as covariates in statistical analyses.
Significant changes in weight, depression, visio-spatial memory, perceptual disembedding abilities, and verbal fluency were observed. Changes in weight had a significant effect on improvements in visuo-spatial memory and verbal fluency. Results also revealed a significant effect of depressive symptoms on perceptual disembedding abilities.
The results suggest improvements on a number of neuropsychological functions during the course of CRT. Future studies should explore the use of additional assessment instruments, and include control groups to assess the effectiveness of the intervention.
研究厌食症（AN）青少年在接受认知矫正治疗（CRT）前后的神经心理学功能。
20 名年轻女性 AN 患者参与了个体化 CRT 治疗方案。治疗前后进行神经心理学和精神科评估。体重、抑郁、焦虑、疾病持续时间和饮食障碍病理水平被视为统计分析中的协变量。
体重、抑郁、视空间记忆、知觉分离能力和言语流畅性均有显著变化。体重变化对视空间记忆和言语流畅性的改善有显著影响。结果还显示抑郁症状对知觉分离能力有显著影响。
结果表明，在 CRT 过程中，一些神经心理学功能得到了改善。未来的研究应探索使用其他评估工具，并包括对照组，以评估干预的效果。
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