Department of Transplantation and Vascular Surgery, Korea University College of Medicine, Seoul, Korea.
Department of Biostatistics, Korea University College of Medicine, Seoul, Korea.
Sci Rep. 2021 Jan 12;11(1):783. doi: 10.1038/s41598-020-80266-5.
Recently, waist to hip ratio (WHR) has been reported to be a better indicator of predicting cardiovascular outcomes than body mass index (BMI). We evaluated the effects of pre or post-transplant changes of WHR or BMI on the new onset cardiovascular diseases (CVD) in recipients of kidney transplantation (KT). A total of 572 patients were enrolled from a multicenter observational cohort (KNOW-KT). Measurement of WHR and BMI was done at pre-KT, first and last visit year after KT, and the changes of these parameters and their effect on the incident CVD were analyzed. During the median follow up period of 32.73 ± 15.26 months, the new onset CVD developed in 31 out of 572 patients. The older age, diabetes mellitus and increase of WHR from pre KT or previous follow up year were found to be independent factors predicting the new onset CVD in these patients. However, baseline BMI, WHR prior to KT did not predict the incident CVD. The new metabolic burden, presented as increase of WHR in KT patients has a critical impact on the development of new onset CVD. Strategies to prevent the metabolic burden after KT might improve cardiovascular outcomes and patient's survival.
最近，腰臀比（WHR）被报道为预测心血管结局比身体质量指数（BMI）更好的指标。我们评估了肾移植（KT）受者移植前或移植后 WHR 或 BMI 的变化对新发心血管疾病（CVD）的影响。共从一个多中心观察队列（KNOW-KT）中纳入了 572 名患者。在 KT 前、KT 后第 1 年和最后 1 年就诊时测量 WHR 和 BMI，并分析这些参数的变化及其对新发 CVD 的影响。在中位随访 32.73±15.26 个月期间，572 名患者中有 31 名发生新发 CVD。结果发现，年龄较大、糖尿病和 WHR 从 KT 前或前一年随访时增加是这些患者新发 CVD 的独立预测因素。然而，基线 BMI、KT 前的 WHR 并不能预测新发 CVD。新的代谢负担，表现为 KT 患者 WHR 的增加，对新发 CVD 的发展有重要影响。预防 KT 后代谢负担的策略可能改善心血管结局和患者的生存率。
