Pek Eren, Beyazit Fatma, Korkmaz Nilay Sen
Dr. Eren Pek, Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Canakkale Onsekiz Mart University, Turkey.
Dr. Fatma Beyazit, Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Canakkale Onsekiz Mart University, Turkey.
Pak J Med Sci. 2021 Jan-Feb;37(1):250-255. doi: 10.12669/pjms.37.1.2774.
This study was conducted to evaluate the diagnostic value of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in vaginitis patients.
This cross-sectional retrospective study was performed in Afyon Dinar State Hospital between July 2016 to August 2017. A total of 64 bacterial vaginosis (BV) patients, 66 vulvovaginal candidiasis (VVC) patients and 65 age-matched control subjects were enrolled. NLR, PLR, mean platelet volume (MPV), red cell distribution width (RDW) and other conventional inflammatory marker values were recorded for all patients before and after treatment.
In the BV group, NLR values were found to be elevated compared to VVC and healthy controls [2.9 (1.2-14.7), 2.1 (1.1-11.7) and 2.1 (0.8-7.0), respectively] (p=0.008). Although not found to be statistically significant, the median NLR levels of BV patients decreased from 2.9 (1.2-14.7) to 2.4 (1.2-7.0) after treatment. PLR levels did not show a statistically significant difference between the three groups (p=0.970). The cut-off value of the NLR for BV was 2.19, with 67.2% sensitivity and 63.8% specificity.
The present study demonstrated that NLR levels are elevated in bacterial vaginosis and NLR levels can be used as a reflection of systemic inflammatory response in vaginosis patients.
本研究旨在评估血小板与淋巴细胞比值（PLR）和中性粒细胞与淋巴细胞比值（NLR）在阴道炎患者中的诊断价值。
本横断面回顾性研究于2016年7月至2017年8月在阿菲永迪纳尔州立医院进行。共纳入64例细菌性阴道病（BV）患者、66例外阴阴道假丝酵母菌病（VVC）患者和65例年龄匹配的对照者。记录所有患者治疗前后的NLR、PLR、平均血小板体积（MPV）、红细胞分布宽度（RDW）及其他传统炎症标志物值。
在BV组中，发现NLR值高于VVC组和健康对照组[分别为2.9（1.2 - 14.7）、2.1（1.1 - 11.7）和2.1（0.8 - 7.0）]（p = 0.008）。虽然未发现具有统计学意义，但BV患者治疗后的NLR中位数从2.9（1.2 - 14.7）降至2.4（1.2 - 7.0）。三组之间PLR水平未显示出统计学差异（p = 0.970）。BV的NLR临界值为2.19，敏感性为67.2%，特异性为63.8%。
本研究表明细菌性阴道病患者的NLR水平升高，且NLR水平可作为阴道炎患者全身炎症反应的一个反映指标。
