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Announcing the novel class of GABA-A receptor selective positive allosteric modulator antidepressants.宣布新型GABA-A受体选择性正变构调节剂抗抑郁药。
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Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.加奈索酮（CCD 1042；3α-羟基-3β-甲基-5α-孕烷-20-酮）的抗惊厥特性表征，一种γ-氨基丁酸（A）受体的选择性、高亲和力类固醇调节剂。
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Welcome to volume 8 of .欢迎来到第8卷。 （你提供的原文不完整，缺少具体的书名等信息，这是根据现有内容给出的翻译）
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本文引用的文献

1
Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond.神经甾体作为新型抗抑郁药和抗焦虑药：γ-氨基丁酸A受体及其他。
Neurobiol Stress. 2019 Sep 27;11:100196. doi: 10.1016/j.ynstr.2019.100196. eCollection 2019 Nov.
2
The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents.用于临床的新型抗抑郁药的出现：阿戈美拉汀的矛盾之处与其他新型药物
IBRO Rep. 2019 Jan 9;6:95-110. doi: 10.1016/j.ibror.2019.01.001. eCollection 2019 Jun.
3
Brexanolone: First Global Approval.布雷沙诺龙：全球首次获批。
Drugs. 2019 May;79(7):779-783. doi: 10.1007/s40265-019-01121-0.
4
Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development.产后抑郁症的药物治疗：现有方法和新药研发。
CNS Drugs. 2019 Mar;33(3):265-282. doi: 10.1007/s40263-019-00605-7.
5
A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems.新一代抗抑郁药：基于谷氨酸/GABA 神经递质系统的新型快速作用治疗情绪障碍药物研发管线的最新进展。
Drug Discov Today. 2019 Feb;24(2):606-615. doi: 10.1016/j.drudis.2018.11.007. Epub 2018 Nov 14.
6
Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid) Receptor.神经活性甾体。2. 3α-羟基-3β-甲基-21-(4-氰基-1H-吡唑-1'-基)-19-去甲-5β-孕甾-20-酮（SAGE-217）：一种临床新一代神经活性甾体γ-氨基丁酸受体的正变构调节剂。
J Med Chem. 2017 Sep 28;60(18):7810-7819. doi: 10.1021/acs.jmedchem.7b00846. Epub 2017 Aug 17.
7
Neurosteroids: endogenous role in the human brain and therapeutic potentials.神经甾体：在人类大脑中的内源性作用和治疗潜力。
Prog Brain Res. 2010;186:113-37. doi: 10.1016/B978-0-444-53630-3.00008-7.
8
The GABAergic deficit hypothesis of major depressive disorder.重性抑郁障碍的 GABA 能不足假说。
Mol Psychiatry. 2011 Apr;16(4):383-406. doi: 10.1038/mp.2010.120. Epub 2010 Nov 16.
9
Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy.甘氨酰胺在难治性癫痫儿童和青少年患者中的临床评估。
Epilepsia. 2007 Oct;48(10):1870-4. doi: 10.1111/j.1528-1167.2007.01182.x. Epub 2007 Jul 18.
10
Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice.对γ-氨基丁酸（GABA）受体具有正向调节作用的别孕烯醇酮类似物可保护小鼠免受6赫兹电刺激诱发的局灶性癫痫发作。
Epilepsia. 2004 Jul;45(7):864-7. doi: 10.1111/j.0013-9580.2004.04504.x.

Announcing the novel class of GABA-A receptor selective positive allosteric modulator antidepressants.

作者信息

Fasipe Olumuyiwa John, Agede Olalekan Ayodele, Enikuomehin Adenike Christiana

机构信息

Department of Clinical Pharmacology & Therapeutics, Faculty of Basic Clinical Sciences, University of Medical Sciences, Ondo City, Ondo State, Nigeria.

Department of Clinical Pharmacology & Therapeutics, Faculty of Basic Clinical Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria.

出版信息

Future Sci OA. 2020 Nov 12;7(2):FSO654. doi: 10.2144/fsoa-2020-0108.

DOI:10.2144/fsoa-2020-0108
PMID:33437518
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7787135/
Abstract
摘要