Nemoto R, Uchida K, Tsutsumi M, Koiso K, Satoh T
Department of Urology, University of Tsukuba, Ibaraki, Japan.
J Urol. 1988 Mar;139(3):650-2. doi: 10.1016/s0022-5347(17)42552-3.
The high incidence of metastatic bone resorption in urological cancer makes it necessary for clinicians to look for a valid experimental model to investigate basic interaction between cancer cells and bone in order to improve the treatment. A new model of bone resorption has been defined, namely the subcutaneous injection of tumor cell suspensions of invasive transitional cell carcinoma of the bladder (MBT-2) into mice after the periosteum of the calvaria has been disrupted. The tumor induced osteolysis associated with osteoclast proliferation with reactive bone formation. Moreover, we were able to show hypercalcemia accompanied with local bone resorption in this model.
泌尿系统癌症中转移性骨吸收的高发生率使得临床医生有必要寻找一个有效的实验模型来研究癌细胞与骨骼之间的基本相互作用，以改善治疗效果。一种新的骨吸收模型已被确定，即在破坏小鼠颅骨骨膜后，皮下注射膀胱浸润性移行细胞癌（MBT-2）的肿瘤细胞悬液。该肿瘤诱导了与破骨细胞增殖及反应性骨形成相关的骨溶解。此外，我们能够在该模型中证明伴有局部骨吸收的高钙血症。
