Master of Science in Geriatric Dentistry, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California, USA.
Division of Restorative Dentistry, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California, USA.
Spec Care Dentist. 2021 Mar;41(2):251-270. doi: 10.1111/scd.12562. Epub 2021 Jan 13.
The objective of this systematic review was to evaluate the efficacy of denture adhesives (DAs) in completely edentulous denture wearers compared to not using DAs.
PubMed, Web of Science, Cochrane Library, and EMBASE were searched from the database inception up to 6 February 2020 for Randomized Controlled Trials (RCTs) involving patients with complete dentures in both arches where the use of DAs was compared to no use of DAs. A total of 497 abstracts were reviewed, resulting in inclusion of 10 RCTs. Outcomes reported in the included trials were thoroughly reviewed and tabulated. The Cochrane risk of bias tool was used. All 10 studies were assessed at unclear (10%) or high risk of bias (90%). Studies showed DAs improved mainly retention/stability, and masticatory/chewing ability/performance, compared to no adhesives.
Most studies showed favorable results for DAs on retention and stability of complete dentures, masticatory performance, patient's comfort and satisfaction. Due to the heterogeneity of the outcomes, unclear/high risk of bias and small sample sizes, the quality of the evidence was very low. More high-quality research is needed with improved blinding and use of standardized methods to evaluate the efficacy of DAs.
本系统评价旨在评估义齿黏附剂（DAs）在全口义齿佩戴者中的疗效，与不使用 DAs 进行比较。
从数据库建立到 2020 年 2 月 6 日，通过 PubMed、Web of Science、Cochrane 图书馆和 EMBASE 搜索了涉及双颌全口义齿患者的随机对照试验（RCTs），其中比较了使用 DAs 与不使用 DAs。共审查了 497 篇摘要，纳入了 10 项 RCT。对纳入试验中报告的结果进行了彻底审查和制表。使用了 Cochrane 偏倚风险工具。10 项研究均被评为不确定（10%）或高风险（90%）偏倚。研究表明，与不使用黏附剂相比，DAs 主要改善了义齿的固位/稳定性以及咀嚼/咀嚼能力/性能。
大多数研究表明，DAs 在全口义齿的固位和稳定性、咀嚼性能、患者的舒适度和满意度方面具有良好的效果。由于结果的异质性、不确定/高偏倚风险和样本量小，证据质量非常低。需要更多高质量的研究，采用改进的盲法和标准化方法来评估 DAs 的疗效。
