Departamento de Microbiologia e Parasitologia, Instituto Biomédico, Universidade Federal Fluminense (UFF), Rua Professor Hernani Melo 101, Niterói, RJ 22430 190, Brazil.
Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Avenida Brasil 4365, Manguinhos, RJ 21040 360, Brazil.
Future Microbiol. 2021 Jan;16(1):37-50. doi: 10.2217/fmb-2020-0123.
Since the first evidence of human parvovirus B19 (B19V) infection in late 80s, several studies have been conducted to clarify the spectrum of clinical diseases in Brazil. B19V infection is prevalent in the general population and has exhibited a cyclical pattern of occurrence every 4-5 years, with the predominance of genotype 1 over 3b. During epidemic periods the wide range of clinical conditions, such as ertythema infectiosum, arthropathy, transient aplastic crisis, nonimmune hydrops fetalis and B19V-hepatitis were diagnosed. However, many infections are likely asymptomatic or have a self-limiting clinical course and are not readly diagnosed. Besides, the similarity of the symptoms of ertythema infectiosum to other rash diseases and the broadly circulation of arboviruses makes differential diagnosis more difficult. In this article, we provide a historical comprehensive overview of the research on parvovirus B19 conducted in Brazil, with a focus on the clinical and epidemiological aspects of the infection.
自 80 年代末发现首例人类细小病毒 B19（B19V）感染以来，已有多项研究旨在阐明巴西的临床疾病谱。B19V 感染在普通人群中普遍存在，呈每 4-5 年周期性发生的模式，1 型基因型比 3b 型更为常见。在流行期间，广泛诊断出多种临床病症，如传染性红斑、关节病、一过性再生障碍性危象、非免疫性胎儿水肿和 B19V 肝炎。然而，许多感染可能无症状或具有自限性临床过程，不易诊断。此外，传染性红斑的症状与其他皮疹疾病相似，以及虫媒病毒的广泛传播，使得鉴别诊断更加困难。本文对巴西开展的关于细小病毒 B19 的研究进行了历史综述，重点关注感染的临床和流行病学方面。
