Brunsting L A, Salter D R, Murphy C E, Abd-Elfattah A S, Goldstein J P, Wechsler A S
Department of Surgery, Duke University Medical Center, Durham, NC 27710.
J Thorac Cardiovasc Surg. 1988 Mar;95(3):432-41.
Load-independent pressure-dimension analysis was applied in 13 open-chest, anesthetized dogs during either left atrial (n = 7) or right atrial (n = 6) infusion of prostaglandin E1. Right atrial infusion of prostaglandin E1 in doses from 31 to 500 ng/kg/min resulted in no change in any parameters studied, including mean arterial pressure, cardiac output, and systemic and pulmonary vascular resistances. Left atrial infusion of prostaglandin E1 produced dose-dependent reductions in mean arterial pressure and systemic vascular resistance but no change in the slope of the relationship of left ventricular stroke work to end-diastolic length, a load-independent index of ventricular performance. In contrast to findings obtained with load-dependent parameters, these results suggest that prostaglandin E1 has no positive inotropic effect in vivo.
在13只开胸、麻醉的犬中进行了负荷独立压力-维度分析，在左心房（n = 7）或右心房（n = 6）输注前列腺素E1期间进行。以31至500 ng/kg/分钟的剂量右心房输注前列腺素E1，所研究的任何参数均无变化，包括平均动脉压、心输出量以及体循环和肺循环血管阻力。左心房输注前列腺素E1使平均动脉压和体循环血管阻力呈剂量依赖性降低，但左心室每搏功与舒张末期长度关系的斜率无变化，舒张末期长度是心室功能的负荷独立指标。与负荷依赖性参数的研究结果相反，这些结果表明前列腺素E1在体内无正性肌力作用。
