Department of Cardiac Surgery, Helios Klinikum Krefeld, Germany.
Department of Thoracic and Cardiovascular Surgery, University of Thessaly, Larissa, Greece.
Braz J Cardiovasc Surg. 2021 Feb 1;36(1):112-115. doi: 10.21470/1678-9741-2020-0379.
A 71 year-old male with a history of multiple excisions of an initial Clark's level V melanoma of the breast followed by combined radiation and interferon treatment, as well as a recurrence, 3 years later, of a BRAF-positive tumor of the shoulder, with subsequent therapy with dabrafenib and trametinib, presented again with progressive intracardiac masses causing significant right ventricular outflow obstruction. Additionally, the patient complained of dyspnea and fatigue on exertion, thus he was scheduled for surgical resection.
一位 71 岁男性，既往有多次乳房初始 Clark 分级 V 期黑色素瘤切除术史，随后接受联合放疗和干扰素治疗，3 年后肩部出现 BRAF 阳性肿瘤复发，随后接受达布拉非尼和曲美替尼治疗，再次出现进行性心内肿块，导致右心室流出道严重梗阻。此外，患者诉活动时呼吸困难和疲劳，因此安排手术切除。
