Schulz G B, Volz Y, Jokisch F, Casuscelli J, Eismann L, Pfitzinger P, Stief C G, Schlenker B
Urologische Klinik und Poliklinik, LMU Klinikum München, Marchioninistr. 15, 81377, München, Deutschland.
Urologe A. 2021 Feb;60(2):162-168. doi: 10.1007/s00120-020-01435-y. Epub 2021 Jan 13.
Radical cystectomy is associated with considerable morbidity and mortality. Based on the solid evidence in colorectal surgery, fast-track/ERAS® (Enhanced Recovery After Surgery) protocols have been developed to improve the perioperative management of patients undergoing radical cystectomy.
To review the literature and guidelines and evaluate the evidence regarding the different components of ERAS® protocols.
Systemic literature search and evaluation of relevant guidelines.
The majority of ERAS® recommendations for radical cystectomy are based on extrapolations of abdominal surgery studies. Four randomized, controlled trials and one ERAS® guideline were published for radical cystectomy. ERAS® seems to shorten length of stay without increasing the complication rate. Key elements are no bowel preparation, no nasogastric tube, optimized fluid substitution, multimodal pain management, early mobilization, and oral diet.
Implementation of ERAS® requires multidisciplinary collaboration. Individualization of an ERAS® program, identification of the most important components and adaption to the specific needs of radical cystectomy patients are future goals.
根治性膀胱切除术与相当高的发病率和死亡率相关。基于结直肠手术的可靠证据,已制定快速康复/加速康复外科(ERAS®)方案以改善接受根治性膀胱切除术患者的围手术期管理。
回顾文献和指南并评估关于ERAS®方案不同组成部分的证据。
系统的文献检索和相关指南的评估。
大多数关于根治性膀胱切除术的ERAS®建议是基于腹部手术研究的推断。已发表了四项关于根治性膀胱切除术的随机对照试验和一项ERAS®指南。ERAS®似乎可缩短住院时间且不增加并发症发生率。关键要素包括不进行肠道准备、不放置鼻胃管、优化液体补充、多模式疼痛管理、早期活动和经口进食。
实施ERAS®需要多学科协作。ERAS®方案的个体化、确定最重要的组成部分以及适应根治性膀胱切除术患者的特定需求是未来的目标。